SynthesisAnnals of medicine2025
Association of subclinical thyroid dysfunction with the risk of vertebral fracture: a meta-analysis of prospective cohort studies.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubclinical thyroid dysfunction (STD) is associated with an elevated risk of non-vertebral fractures. However, whether STD is associated with the risk of vertebral fracture remains controversial. This study aimed to determine the relationship between STD and the risk of vertebral fracture using a meta-analysis approach. MATERIALS AND
methodsPubMed, Embase, and the Cochrane Library databases were searched for eligible studies published until March 01, 2025. Only prospective cohort studies that reported effect estimates with 95% confidence intervals (CIs) of vertebral fractures in participants with subclinical hyperthyroidism (SCH) and subclinical hypothyroidism (SH) compared to those with euthyroidism were included. A random-effects model was used to pool risk ratios (RRs), and analyses accounted for key covariates, including demographic factors, lifestyle variables, and disease history where reported.
resultsTen prospective cohort studies involving 61,219 individuals were included in this meta-analysis. SCH was associated with an increased risk of vertebral fracture (RR: 2.20; 95% CI: 1.60-3.02;
conclusionOur study found that SCH was an independent risk factor for vertebral fracture, and that SH may increase the risk of vertebral fracture. Clinically, these findings support the need for regular monitoring of thyroid function, particularly in older adults, to identify individuals with STD who may benefit from targeted interventions to reduce vertebral fracture risk.
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