Evidence map›Paper›PMID 40936288›Full record

ArticleBipolar disorders2025

A Cross-Sectional Analysis of Social Determinants of Health in Bipolar Disorder: Exploring Gender-Related Differences.

Manuel Gardea-Resendez, Manuel Fuentes-Salgado, Francisco Romo-Nava, Miguel L Prieto, David J Bond, Aysegul Ozerdem, Hannah K Betcher, Katherine M Moore, Melissa Solares-Bravo, Mete Ercis and 10 more

Abstract read
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In one paragraph

Article in Bipolar disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Manuel Gardea-ResendezDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9825-8792
Manuel Fuentes-SalgadoDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Francisco Romo-NavaLindner Center of Hope, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-5894-3701
Miguel L PrietoDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5578-4605
David J BondDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-8713-7311
Aysegul OzerdemDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Hannah K BetcherDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Katherine M MooreDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Melissa Solares-BravoDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Mete ErcisDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-1272-5503
Alessandro MiolaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2513-2718
Jorge A Sanchez-RuizDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-4282-7359
Marin VeldicDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Balwinder SinghDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-7062-8192
Alfredo B Cuellar-BarbozaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-9350-4440
Susan L McElroyLindner Center of Hope, University of Cincinnati, Cincinnati, Ohio, USA.
Monica J Taylor-DesirDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6997-4215

Funding

International Society for Bipolar DisordersJ. Willard and Alice S. Marriott Foundation
6 · The paper itself

Abstract

objectivesTo explore the clinical impact of social determinants of health (SDoH) stress in bipolar disorder (BD) course of illness and to explore potential gender differences in SDoH stress endorsement.

methods2280 individuals living with BD type I or II (62% women; 67.5% BD-I) participating in the Mayo Clinic Bipolar Biobank who completed a questionnaire assessing positive and negative-valent stressors in the 12 months prior to study enrollment were included for this analysis. Six negative stressors were used as proxies of SDoH. Generalized linear models were used to test the association between SDoH stressors and markers of illness severity as well as potential differences by sex by including an interaction term.

resultsAfter adjusting for age, sex, and recruitment site, SDoH-related stressors were significantly associated with a more severe course of illness in both men and women. Except for unemployment rates, women reported more frequently SDoH-related stress (i.e., lack of family support, financial problems, health coverage and access problems).

conclusionsThe study found significant gender differences in both the endorsement of specific SDoH stressors and in the prevalence of specific illness severity markers; however, it did not directly test the predictive relationship between gender differences in SDoH and illness severity markers. Future studies aiming to achieve health equity in mental health care should continue assessing social determinants of health stressors, incorporating a gender perspective to better understand their influence on bipolar disorder.

Indexed as

Bipolar DisorderSex CharacteristicsSocial Determinants of HealthStress, PsychologicalAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexSex Factorsbipolar disordersex differencessocial determinants of healthstress

Identifiers

PMID40936288
PMCPMC12706543

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.