ArticleJournal of veterinary science2025
Steroid hormone-treated endometrial organoids enhance implantation of
Article in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
importanceEmbryo implantation is a hormone-regulated event requiring a receptive endometrium.
objectiveThis study aimed to verify the response of porcine EEOs to steroid hormones and assess how steroid hormones affect embryonic attachment in a culture medium containing EEOs.
methodsDuring a 7-day organoid
resultsThe results demonstrated a higher receptor expression level in the hormone-treated groups than that in the control group. Additionally, the expression levels of genes associated with E₂ (fibroblast growth factor 7 and insulin-like growth factor 1) and P₄ (transforming growth factor β1) were higher in the hormone-treated group as compared to those in the control group. The efficiency of embryonic attachment was assessed through co-culture with EEOs harvested from both groups on the 7 CONCLUSION AND RELEVANCE: This study confirmed that porcine endometrial organoids respond to steroid hormones and support embryo attachment. These findings provide a translational basis for developing
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