Evidence map›Paper›PMID 40936231›Full record

ReviewExpert reviews in molecular medicine2025

From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function.

Jesús Manuel Rodríguez Rego, Laura Mendoza Cerezo, Francisco de Asís Iñesta Vaquera, David Picado Tejero, Alfonso Carlos Marcos Romero

Abstract readReview
In one paragraph

Review in Expert reviews in molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jesús Manuel Rodríguez RegoDepartamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Badajoz, España.ORCID 0000-0003-4533-8067
Laura Mendoza CerezoDepartamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Badajoz, España.ORCID 0000-0003-2282-4409
Francisco de Asís Iñesta VaqueraDepartamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, España.ORCID 0000-0002-4579-7418
David Picado TejeroDepartamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Badajoz, España.ORCID 0009-0000-4191-5328
Alfonso Carlos Marcos RomeroDepartamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Badajoz, España.ORCID 0000-0002-0882-4210

Funding

Interreg 0140_BIOIMP_ACE_MAS_6_E
6 · The paper itself

Abstract

backgroundThe rapid advancement of 3D bioprinting is transforming possibilities in tissue engineering and personalised medicine, offering innovative solutions to critical biomedical challenges such as organ shortages and the need for precise 3D cellular models. To fully unlock the potential of this technology, anoptimised and comprehensive workflow is essential.

methodsThis review provides a systematic examination of the bioprinting process, covering key steps from medical image acquisition to the validation of bioprinted structures. The analysis includes biomaterial and cell type selection, conversion of DICOM images into 3D-printable models, and slicing techniques.

resultsKey factors influencing the precision, viability, and clinical relevance of bioprinted tissues are identified. Comparisons between planar and non-planar slicing algorithms highlight their impact on scaffold integrity. The review also discusses advancements in algorithm development, bioprinter technology, and biomaterial optimisation, emphasising their role in enhancing reproducibility and functionality.

conclusionsThis structured review offers actionable insights for researchers and practitioners aiming to refine bioprinting workflows. By integrating improvements across imaging, modelling, and material selection, 3D bioprinting can more effectively support the development of clinically relevant constructs, advancing regenerative medicine and personalisedhealthcare.

Indexed as

BioprintingDiagnostic ImagingTissue EngineeringAnimalsBiocompatible MaterialsHumansPrinting, Three-DimensionalRegenerative MedicineTissue ScaffoldsWorkflowBiocompatible Materials3D bioprintingcell viability and functionfunctional hydrogelsimage processingmodellingpersonalised medicine

Identifiers

PMID40936231
PMCPMC12558632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.