ReviewJournal of neuroendocrinology2025
Cellular mechanisms of long-term osmoregulation in magnocellular neurons.
Review in Journal of neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cellular mechanisms of long-term osmoregulation in magnocellular neurons.Journal of neuroendocrinology · 2025Review
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Authors and funding
2 authors.
Funding
Abstract
Osmoregulation is an essential homeostatic process that maintains the osmolality of the extracellular fluid (ECF) close to a physiological setpoint. Vasopressin (VP) plays a key role in osmoregulation and is secreted by the magnocellular neurosecretory cells (MNCs) of the hypothalamus. MNC electrical activity and VP release increase with elevations of ECF osmolality. MNC osmosensitivity depends on a mechanosensitive N-terminal variant of the transient receptor potential vanilloid type 1 (ΔN-TRPV1) channel that activates in response to osmotically induced cell shrinkage. ΔN-TRPV1 mechanosensitivity depends on their association with microtubules in the MNC cytoskeleton and is modulated by a dense layer of submembranous actin in MNC somata. MNCs exposed to sustained increases in osmolality, however, undergo marked somatic hypertrophy, which suggests that other mechanisms may be important to maintain VP release. Recent evidence suggests that the translocation of ΔN-TRPV1 (and possibly other channels) to the MNC cell surface could contribute to osmotically induced long-term increases in MNC excitability. Osmotically induced ion channel translocation is dependent on MNC firing, Ca
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