Evidence map›Paper›PMID 40936085›Full record

ArticleJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2026

Investigation of the Telomere Length in PERI-Implant Oral Mucosa Cells.

Fernando Costa Giffoni, Thaís Ellen Chaves Gomes, Priscila Nazaré de Souza, Paula Valente E Silva, Luiz Alexandre Viana Magno, Amanda Lage Cândido, Marcelo Faria Lasmar, Sebastião Guilherme de Oliveira Neto, Marcus Vinicius Lucas Ferreira, Thiago Moreira Gonçalves Araujo and 4 more

Abstract read
In one paragraph

Article in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Investigation of the Telomere Length in PERI-Implant Oral Mucosa Cells.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fernando Costa GiffoniFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Thaís Ellen Chaves GomesSchool of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0009-0002-7798-4354
Priscila Nazaré de SouzaFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Paula Valente E SilvaFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Luiz Alexandre Viana MagnoFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Amanda Lage CândidoFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Marcelo Faria LasmarFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Sebastião Guilherme de Oliveira NetoFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Marcus Vinicius Lucas FerreiraSchool of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Thiago Moreira Gonçalves AraujoFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Luara Isabela Dos SantosSchool of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Bruno Ramos ChrcanovicDepartment of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-3460-3374
Ricardo Santiago GomezFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-8770-8009
Roberta Rayra Martins-ChavesFaculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoFundação de Amparo à Pesquisa do Estado de Minas Gerais
6 · The paper itself

Abstract

backgroundThe biological effects of dental implants on peri-implant tissues have been widely investigated. Recent reports of oral squamous cell carcinoma (OSCC) cases adjacent to dental implants have raised concerns regarding the potential impact of implant materials on cellular aging and oncogenic transformation. Telomeres, which protect chromosome ends, undergo progressive shortening and play a critical role in cellular senescence and tumorigenesis. However, the impact of dental implants on telomere length in peri-implant mucosa remains unclear.

objectiveThis study aimed to compare telomere length in mucosa adjacent to dental implants with that of gingival tissue associated with healthy teeth.

methodsA paired cross-sectional study was conducted with 16 patients who had dental implants for at least 1 year. Swabs were collected from the peri-implant mucosa and healthy gingival mucosa of the same patient. Telomere length was assessed using quantitative PCR, with the relative telomere-to-single-copy-gene ratio (T/C) calculated using the 2

resultsTelomere length in the peri-implant mucosa was not significantly different from that in the healthy gingival mucosa (p = 0.117).

conclusionThese findings suggest that dental implants do not alter telomere length in adjacent mucosal cells.

Indexed as

Dental ImplantsMouth MucosaTelomereAdultAgedCross-Sectional StudiesFemaleGingivaHumansMaleMiddle AgedDental Implantsbiocompatibilitycellular senescencedental implantsperi‐implant mucosatelomere length

Identifiers

PMID40936085
PMCPMC12774569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.