ArticleJournal of assisted reproduction and genetics2025
Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Advances in Male Reproductive Toxicology of Nanoplastics: Potential Risks to Human Reproduction-A Systematic Review.International journal of molecular sciences · 2026Pooled it
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Authors and funding
4 authors.
Funding
Abstract
purposeThis study aimed to identify kisspeptin as a new marker for infertility in men with abnormal semen parameters by comparing serum and seminal plasma kisspeptin levels between fertile men and infertile men with normal and abnormal semen parameters.
methodsFertile men (group A), infertile men with normal semen parameters (group B), and infertile men with abnormal semen parameters (group C) were recruited. Fasting venous blood was tested for kisspeptin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, insulin-like growth factor 1 (IGF-1), insulin, and glucose. Semen was collected by self-masturbation, and semen analysis was performed, then was tested for kisspeptin and testosterone.
resultsFifty-two men were included in the study (17 fertile men in group A, 18 infertile men in group B, and 17 infertile men in group C). Serum kisspeptin levels were significantly lower in fertile men (group A) as compared to infertile men (groups B and C) regardless to semen parameters (85.18 ± 20.47 ng/dL, 109.37 ± 28.64 ng/dL, and 108.70 ± 32.30 ng/dL respectively; p = 0.019). While seminal plasma kisspeptin levels were not significantly different (245.95 ± 67.12 ng/dL, 283.73 ± 119.82 ng/dL, and 312.99 ± 245.17 ng/dL, respectively; p = 0.48). There was no significant difference among groups for serum FSH, LH, testosterone, IGF-1, fasting insulin, fasting glucose, homeostasis model assessment of insulin resistance (HOMA-IR), and seminal plasma testosterone.
conclusionSerum kisspeptin might be used as a more sensitive marker for male infertility rather than FSH and LH. However, the clinical application of kisspeptin in the treatment of male infertility requires further study.
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