Evidence map›Paper›PMID 40936047›Full record

ArticleTranslational stroke research2025

Differential Effects of Murine Stroke Models on Dopaminergic Neurons, Glial Responses, and Neurobehavioral Outcomes.

Sidra Tabassum, Heng Hu, Silin Wu, Shuning Huang, Bosco Seong Kyu Yang, Chang-Hun Lee, Aaron W Gusdon, Xuefang S Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sidra TabassumDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Heng HuDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Silin WuDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Shuning HuangDepartment of Diagnostic and Interventional Imaging, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Bosco Seong Kyu YangDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Chang-Hun LeeDepartment of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
Aaron W GusdonDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Xuefang S RenDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Xuefang.ren@uth.tmc.edu.

Funding

A Novel Blood Substitution Approach Treats Acute Ischemia in the Aged BrainRF1AG073659 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI REN, XUEFANG SOPHIE · 2025 to 2025
$2.5M
MicroRNAs, Mitochondria and the Blood-Brain Barrier - Therapeutic Targets for StrokeR01NS117606 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xuefang Sophie Ren · 2023 to 2026
$1.8M
Metabolic alterations after aneurysmal subarachnoid hemorrhageK23NS121628 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Aaron Mark Gusdon · 2022 to 2026
$924k
A Novel Blood Substitution Approach Treats Acute Ischemia in the Aged BrainR01AG073659 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI REN, XUEFANG SOPHIE · 2024 to 2024
$645k
National institute of aging (NIA) 1R01AG073659National science foundation (NSF) 1916894NIA NIH HHS R01 AG073659NIA NIH HHS RF1 AG073659NINDS NIH HHS 1R01NS117606NINDS NIH HHS K23NS121628NINDS NIH HHS R01 NS117606University of Texas Health Science Center at Houston new faculty start-up funds
6 · The paper itself

Abstract

Stroke is a leading cause of disability worldwide, often resulting in persistent motor, cognitive, and emotional impairments. While the hippocampus and amygdala play critical roles in post-stroke behavioral changes, specific neuronal alterations and prolonged glial responses within these regions across different stroke types remain unclear. This study investigates the behavioral, neuronal, and glial effects of subarachnoid hemorrhage (SAH), transient middle cerebral artery occlusion (tMCAO), and photothrombotic stimulation (PTS) in mice. SAH and tMCAO models exhibited significant motor deficits, spatial and recognition memory impairments, and increased anxiety- and depressive-like behaviors, whereas the PTS model showed similar motor and cognitive impairments but lacked affective (anxiety- and depressive-like) behavioral changes. Immunohistochemical analysis revealed increased overlap of tyrosine hydroxylase (TH, a dopaminergic marker) process with NeuN (a neuronal marker) in the dentate gyrus (DG) of SAH and tMCAO mice, highlighting region-specific vulnerability to ischemic damage in the hippocampus. In the amygdala, elevated overlap of TH

Indexed as

Dopaminergic NeuronsNeurogliaStrokeAmygdalaAnimalsBehavior, AnimalDisease Models, AnimalHippocampusInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLCognitive impairmentsEmotional dysregulationMotor deficitsPhotothrombotic stimulationStrokeStroke modelsSubarachnoid hemorrhageTransient middle cerebral artery occlusion

Identifiers

PMID40936047
PMCPMC12596347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.