SynthesisGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Corneal stability comparison between prophylactic cross-linking with laser refractive surgery technique versus laser refractive surgery technique alone for myopia: a meta-analysis.
Synthesis in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo summarize whether corneal cross-linking (CXL) with laser refractive surgery improves corneal stability more than laser surgery alone for myopia.
methodsFive electronic databases were systematically searched from inception to Aug, 2023. Studies comparing the effects of prophylactic corneal CXL with laser refractive surgery technique versus laser refractive surgery technique alone in myopic eyes were included. The included articles regarding prophylactic CXL combination with laser refractive surgery technique, riboflavin was all delivered into the stroma with similar accelerated protocols (irradiance of 30mW/cm
resultsTwelve eligible studies with 1,252 eyes met our inclusion criteria. Compared to those receiving laser refractive surgery technique alone, patients who received prophylactic CXL with laser refractive surgery technique had significantly less UDVA and CDVA decrease within post-operative 12 months (UDVA:WMD -0.04, 95% CI -0.06-(-0.01), p=0.01/CDVA: WMD -0.01, 95% CI -0.03-(-0.00), p=0.02). Furthermore, patients with spherical equivalent
conclusionFor visual outcome, prophylactic CXL with laser refractive surgery, compared to laser refractive surgery alone, provided more stability within post-operative one-year among myopic patients with comparable efficacy and predictability. Particularly, those with higher myopia or receiving LASIK procedure as refractive surgery benefited more from prophylactic CXL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.