ReviewCurrent osteoporosis reports2025
Bone Marrow Adipoq-lineage Progenitors: an Emerging Osteoclast Niche Cell Population.
Review in Current osteoporosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms.Frontiers in endocrinology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purpose of reviewThe purpose of this review is to summarize and highlight the recent findings of a novel osteoclastic niche centered on the bone marrow Adipoq-lineage progenitors. We will focus on these novel discoveries to help understand the impact of the unique bone marrow Adipoq-lineage cells on osteoclasts, the bone marrow milieu and the skeleton, discuss the similarities and differences between the Adipoq-lineage cells and other bone marrow stromal progenitors, as well as some important questions that draw increasing attention and need to be addressed. RECENT
findingsOsteoclasts are the exclusive bone-resorbing cells important for bone homeostasis. Osteoclastogenesis is essentially induced by Macrophage colony-stimulating factor (M-CSF) and Receptor activator of nuclear factor kappa-Β ligand (RANKL), meanwhile regulated by other cytokines. Osteoblasts have been long believed to be the major partners of osteoclasts through secretion of M-CSF and RANKL. However, recent groundbreaking findings challenged this traditional model and identified the bone marrow Adipoq-lineage progenitors, not osteoblasts or mature adipocytes, as the main cell type supporting osteoclastogenesis through producing M-CSF, RANKL and other osteoclastogenic cytokines. Recent evidence suggests that the functional impact of the bone marrow Adipoq-lineage progenitors on macrophage lineage development and osteoclastogenesis is very significant. Future studies are expected to elucidate the lineage specification of this cell population and how signaling pathways and environmental cues shape this unique osteoclastic niche in physiological and pathological conditions.
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