ArticleEuropean radiology experimental2025
Appearance of myocarditis lesions on spectral CT arterial acquisitions and correlation with edema on MRI.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.European radiology experimental · 2026Pooled it
- Spectral computed tomography as a novel diagnostic tool for mushroom poisoning-induced myocarditis: a case report.European heart journal. Case reports · 2026Article
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Abstract
backgroundSpectral computed tomography (CT) late-enhancement (LE) acquisitions can help detect myocarditis. An arterial acquisition is often performed for coronary artery analysis. However, little is known about the appearance of myocarditis on the arterial phase. We investigated the appearance of myocarditis on arterial acquisitions of cardiac spectral CT, and its relationship to LE and edema. MATERIALS AND
methodsForty-seven cardiac spectral CTs performed in patients with magnetic resonance imaging (MRI)-confirmed myocarditis were retrospectively assessed. Three myocardial attenuation/enhancement patterns were visually identified and segmented on both arterial and LE acquisitions: hypodense-arterial + normal-LE (HypoArt-NorLE); normal-arterial + hyperdense-LE (NorArt-HyperLE); and hypodense-arterial + hyperdense-late (HypoArt-HyperLE). Characteristics of conventional and spectral images were calculated for all patterns and for remote myocardium. Values of HypoArt-HyperLE lesions were compared in the groups with and without edema on MRI, as assessed with T2 mapping (available for 25 patients).
resultsWe found 173 lesions, 46 (26%) HypoArt-NorLE, 54 (31%) NorArt-HyperLE, and 73 (42%) HypoArt-HyperLE. On the arterial phase, HypoArt-HyperLE were more hypodense (p < 0.001) and had less iodine (0.23 mg/mL less; p < 0.001) than RM. On LE, both HypoArt-HyperLE and NorArt-HyperLE were more hyperdense and contained more iodine than the remote myocardium (all p < 0.001). HypoArt-HyperLE lesions were more hypodense and contained less iodine on the arterial phase in patients with edema on MRI as compared to those without (all p < 0.001).
conclusionMost myocarditis lesions detectable with spectral CT are visible on both arterial and LE acquisitions. These lesions appeared to be more pronounced on the arterial phase in patients with edema on MRI. RELEVANCE STATEMENT: Spectral CT arterial acquisition performed for the differential diagnosis of acute myocardial pathologies in many cases can depict myocarditis lesions as epicardial hypodense areas, most likely related to the presence of edema. KEY POINTS: Data from spectral CT shows that most myocarditis lesions appear as hypodense on the arterial phase, matching the epicardial LE zones. A minority of myocarditis lesions appear as epicardial LE areas without anomalies of attenuation on the arterial phase. Hypodense myocardial areas are correlated to the presence of edema on MRI, suggesting they are due to the same phenomenon.
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