ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Motor signs in late life depression relate to altered subcortical synaptic density and gray matter volume: an
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Synaptic density in the hippocampus of depressed patients: A quantitative electron microscopic study.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
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Abstract
Motor signs are common in patients with a major depressive disorder (MDD) and associated with functional disability and falls. They appear to be more pronounced in patients with late life depression, but it is unclear whether this is caused by global brain aging or by a specific pathology associated with depression. We therefore sought to investigate associations between motor signs in late life depression and aging related changes in synapses, gray and white matter. From the monocentric Leuven Late Life depression study, we included 75 participants (41 healthy controls, 34 currently depressed MDD patients) aged ≥ 60 years. Motor assessment included the MDS-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRSIII), Scale for Assessment and Rating of Ataxia (SARA), gait analysis and digitized drawing. Brain synaptic vesicle glycoprotein 2A binding as a proxy for synaptic density was determined in predefined cortico-subcortical volumes of interest (VOI) using
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