Evidence map›Paper›PMID 40935866›Full record

ArticleArchives of toxicology2025

Inhibitory effects of 6-O-palmitoyl-L-ascorbic acid (ASC16) on the enzymatic activity of Bothrops alternatus venom.

Franco Maslovski, Jaime Andrés Pereañez, David Hernández, María Alonso, Silvina Echeverría, Carolina Gay, Laura Leiva, Emilio Angelina, Luciano Fusco

Abstract read
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In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Brief history of ophidiology and ophidism in Colombia.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Franco MaslovskiConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina.
Jaime Andrés PereañezGrupo de Investigación Promoción y Prevención Farmacéutica, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia UdeA, 050001, Medellín, Colombia.
David HernándezFacultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, W3400, Corrientes, Argentina.
María AlonsoConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina.
Silvina EcheverríaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina.
Carolina GayConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina.
Laura LeivaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina.
Emilio AngelinaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina.
Luciano FuscoConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), W3400, Corrientes, Argentina. luciano.fusco@comunidad.unne.edu.ar.ORCID 0000-0002-7784-6237

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas 11220210100328COSecretaría General de Ciencia y Técnica, Universidad Nacional del Nordeste PI:21F019Secretaría General de Ciencia y Técnica, Universidad Nacional del Nordeste PI:21V001
6 · The paper itself

Abstract

In the anti-venom production process, it is essential to use whole venom during immunization to generate specific antibodies capable of neutralizing all venom components. However, efforts are being made to improve the traditional immunization process by reducing the toxic effects of venom components on the immunized animals while ensuring an optimal immune response in accordance with good manufacturing practices. In this context, we aimed to evaluate the capacity of ASC16 to inhibit the enzymatic activity of the main components of B. alternatus venom. In vitro studies were conducted to evaluate the inhibitory effect of ASC16 on metalloproteinases (SVMP), serine proteinases (SVSP) and phospholipases A

Indexed as

BothropsCrotalid VenomsAnimalsAntiveninsEdemaHemorrhageMaleMetalloproteasesMiceMolecular Docking SimulationPhospholipases A2Venomous SnakesAntiveninsCrotalid VenomsMetalloproteasesPhospholipases A2AntivenomAscorbyl palmitateHemorrhagic venomInhibitorToxins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.