ReviewNature medicine2025
Health impacts of microplastic and nanoplastic exposure.
Review in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in Male Reproductive Toxicology of Nanoplastics: Potential Risks to Human Reproduction-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk.Journal of biochemical and molecular toxicology · 2026Review
- Transcriptomic responses to repeated exposure of human C3A liver spheroids to polystyrene nanoplastics.Archives of toxicology · 2026Article
- The Effects of Microplastics and Trace Elements on Ovarian Function and Pathology: A Literature Review.International journal of molecular sciences · 2026Review
- Clear Aligners as a Prescribed Source of Unmeasured Intra-Oral Micro- and Nanoplastic Exposure: Release Mechanisms, Human Evidence, Salivary Biomonitoring and the EU Regulatory Context.Materials (Basel, Switzerland) · 2026Review
- Nanoplastics as disruptors of microtubule dynamics and intracellular trafficking: implications for cellular senescence and ageing.Molecular and cellular biochemistry · 2026Review
- Review
- Corundum Aggregates With Microplastics Revealed by Raman Scattering and Fluorescence Study of Children's Urine in Hospital Environment.Journal of biophotonics · 2026Article
- The analytical challenge of measuring micro- and nanoplastics in human tissues.Nature nanotechnology · 2026Article
- Measurement Error Models Enable Accurate Correlation of Nanoscale Properties and Structures.ACS nano · 2026Article
- Sustainable Healthcare: A Perspective on the Current Landscape, Frameworks, Barriers, and Implementation Model in a Quaternary Hospital System.International journal of environmental research and public health · 2026Review
- Interfacial Regulation-Driven Dual-Enrichment SERS Coupled With Deep Learning Enable Ultrasensitive and In Situ Identification of Microplastics in Natural Waters.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Update on environmental determinants of allergic diseases.The Journal of allergy and clinical immunology · 2026Review
- Article
- Correspondence on "Mass Balance Tracing of In Vivo Biodistribution, Relocation, and Excretion of Europium-Doped Micro/Nanoplastics in Rats".Environmental science & technology · 2026Article
- Gut-Mediated Systemic Toxicity of Micro- and Nanoplastics: Nanoscale Biointerface Properties, Microbiota-Metabolite Crosstalk, and Evidence Across Gut-Organ Axes.Nanomaterials (Basel, Switzerland) · 2026Review
- Gaps between Laboratory Experiments and Real-World Exposure: Toxicological Assessment of Microplastics Is Based on Inadequate Evidence.Environment & health (Washington, D.C.) · 2026Review
- Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026Review
- Transcriptomic Insights into Micro- and Nanoplastic Toxicity in Zebrafish: A Narrative Review.Toxics · 2026Review
- Microplastics as Vectors Influencing Oxidative Stress, Inflammation, and Endocrine Function During Early Development.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As evidence demonstrating the presence of micro- and nanoplastics (MNPs) in the human body accumulates, so do concerns about their potential health impacts. Multiple factors determine the properties and behavior of MNPs-including polymer type, size, shape and the presence of a biocorona, among others-which place high demands on analytical methodology and tools for assessment of potential adverse health effects. Experimental models have shown that MNPs can cross cell barriers in the human lung and intestine and reach systemic circulation and subsequently tissues such as reproductive organs, placenta and brain. Early clinical findings indicate that MNPs may be associated with adverse health outcomes, including immune modulation, reproductive effects and cardiovascular effects. However, these studies typically suffer from low patient numbers and inadequate MNP exposure assessment, which precludes adequate risk assessment. Still, outcomes from animal and cell-based analyses generally support the preliminary clinical findings. To conduct more robust human studies, maturation of methods for exposure and effect assessment are crucial. Addressing these challenges will improve scientific research on the health impact of MNPs, which is urgently needed.
Indexed as
Identifiers
40935856What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.