ReviewNature genetics2025
Non-CG DNA methylation in animal genomes.
Review in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- LEMONmethyl-seq: Targeted long-read DNA methylation profiling reveals dynamics of CRISPR epigenome editing and endogenous DNA methylation patterns.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosine DNA methylation is widespread in animal genomes and occurs predominantly at CG dinucleotides (mCG). While the roles of mCG, such as in genomic imprinting and genome stability, are well established, non-CG DNA methylation (mCH) remains poorly understood. In most vertebrate tissues, roughly 80% of CGs are methylated, whereas mCH levels are generally low, typically ranging from 1% to 3%. In vertebrates, mCH is most prevalent in neural tissue, oocytes and embryonic stem cells and has been linked to neurodevelopmental disorders. Moreover, mCH appears to have a conserved role in regulating vertebrate neural genomes, and recent studies suggest that it has functions in the embryogenesis of teleost fish. Overall, mCH represents an intriguing emerging aspect of gene regulation with potential implications for cellular identity, repeat silencing and neural function. In this Review, we provide a critical overview of the patterning, mechanisms and functional implications of mCH in animals.
Indexed as
Identifiers
40935851What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.