ArticleNature immunology2025
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration.
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Camouflage Protein-Engineered Extracellular Vesicles Alleviate TMJ-OA by Hijacking Caspase-1 to Suppress Pyroptosis.Journal of extracellular vesicles · 2026Article
- Interleukin-18 armours antitumour immune effectors.Nature reviews. Immunology · 2026Review
- Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Cardiotoxin from Naja atra Activates the NLRP3/Caspase-1/GSDMD Pyroptosis Pathway to Induce Skin Tissue Injury.PLoS neglected tropical diseases · 2026Article
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- Damage-induced pyroptosis drives endogenous thymic regeneration by activating the purinergic receptor P2Y2.Cell death & disease · 2026Article
- Network-orchestrated regulation of thymic dysfunction and restoration.Frontiers in immunology · 2026Review
- From uric acid to tophi: multistage molecular and cellular mechanisms of tophi formation.Frontiers in immunology · 2026Review
- Thymic regeneration and tumor immunotherapy.Frontiers in immunology · 2026Review
- Burning Down the House: Thymic Repair and Regeneration After Acute Damage.Immunological reviews · 2025Review
- Serologic IL-18 increase with B-cell IL-18R loss characterizes selective IgA deficiency.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
David GranadierTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA. dgranadi@fredhutch.org.ORCID http://orcid.org/0000-0002-1983-4190
Kirsten CooperTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0711-2713
Dante AcenasTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Anastasia KousaTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Makya WarrenTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0009-0001-3252-5448
Vanessa HernandezTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lorenzo IovinoTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3165-1899
Paul deRoosTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Emma E LedererTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0009-0008-4103-5388
Steve Shannon-SevillanoTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sinéad KinsellaTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cindy EvandyTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Marcel R M van den BrinkBeckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-0696-4401
Andri LemarquisBeckman Research Institute, City of Hope, Duarte, CA, USA.
Jarrod A DudakovTranslational Science and Therapeutic Division and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA, USA. jdudakov@fredhutch.org.ORCID http://orcid.org/0000-0001-6220-5632
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MThymic and Peripheral Aspects of T Cell Aging and RejuvenationP01AG052359 · NIA · UNIVERSITY OF ARIZONA · PI Jennifer L. Uhrlaub · 2017 to 2026
$23.5MTRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0MPromoting T cell reconstitution after hematopoietic cell transplantationR35HL171556 · NHLBI · FRED HUTCHINSON CANCER CENTER · PI Jarrod Dudakov · 2024 to 2026
$3.6MModulation of signaling from damage-associated molecular patterns to improve radiation-induced thymic dysfunctionU01AI170035 · NIAID · FRED HUTCHINSON CANCER CENTER · PI Jarrod Dudakov · 2022 to 2026
$3.0MHarnessing endogenous mechanisms of thymic regeneration toboost immune function in recipients of hematopoietic cell transplantR01HL145276 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUDAKOV, JARROD · 2019 to 2023
$2.8MRegulation of thymic regeneration by GPR39R01HL165673 · NHLBI · FRED HUTCHINSON CANCER CENTER · PI DUDAKOV, JARROD · 2022 to 2023
$1.2MTargeting IL-18 in Thymic RegenerationF30HL165761 · NHLBI · UNIVERSITY OF WASHINGTON · PI GRANADIER, DAVID WILLIAM · 2023 to 2024
$97kDivision of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U01-AI70035NCI NIH HHS P30 CA015704NHLBI NIH HHS F30 HL165761NHLBI NIH HHS R01 HL145276NHLBI NIH HHS R01 HL165673NHLBI NIH HHS R35 HL171556NIAID NIH HHS U01 AI170035NIA NIH HHS P01 AG052359NIGMS NIH HHS T32 GM007270U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30-CA015704U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL145276U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL165673U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R35-HL171556U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) F30-HL165761U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P01-AG052359
Abstract
Interleukin-18 (IL-18) is an acute-phase proinflammatory molecule crucial for mediating viral clearance by activating T helper 1 CD4
Indexed as
Interleukin-18Killer Cells, NaturalRegenerationThymus GlandAnimalsEpithelial CellsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicInterleukin-18
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.