Evidence map›Paper›PMID 40935730›Full record

ArticleTrends in molecular medicine2025

Two-pronged immune evasion of pseudouridine-modified RNA.

Jonas Cerneckis, Yanhong Shi

Abstract read
In one paragraph

Article in Trends in molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonas CerneckisDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Yanhong ShiDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address: yshi@coh.org.

Funding

Develop age-relevant glial cellular models using human directly reprogrammed cellsR01AG072291 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2021 to 2025
$2.2M
Define the effect of CLU SNP on the risk to Alzheimer's diseaseR01AG079307 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YANHONG SHI · 2025 to 2026
$1.3M
NIA NIH HHS R01 AG072291NIA NIH HHS R01 AG079307
6 · The paper itself

Abstract

It is well established that pseudouridine (Ψ) and its derivative N

Indexed as

Immune EvasionPseudouridineRNAAnimalsHumansToll-Like ReceptorsPseudouridineRNAToll-Like Receptorsimmune evasionmRNA vaccinespseudouridineRNA modificationsRNA therapeuticsToll-like receptors (TLRs)

Identifiers

PMID40935730
PMCPMC12436447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.