Evidence map›Paper›PMID 40935670›Full record

ArticleeNeuro2025

Cell Type-Specific Contributions of UBE3A to Angelman Syndrome Behavioral Phenotypes.

Nicholas W Ringelberg, Renée E Mayfield, Julia S Lord, Graham H Diering, Alain C Burette, Benjamin D Philpot

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicholas W RingelbergNeuroscience Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599-7255.
Renée E MayfieldNeuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599-7255.
Julia S LordNeuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599-7255.
Graham H DieringNeuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599-7255.ORCID https://orcid.org/0000-0001-6113-6946
Alain C BuretteNeuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599-7255.
Benjamin D PhilpotNeuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599-7255 bphilpot@med.unc.edu.ORCID https://orcid.org/0000-0003-2746-9143

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Small Molecule Therapeutic Discovery for Angelman SyndromeR01NS131615 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jeffrey Aube, BENJAMIN D PHILPOT · 2023 to 2026
$2.3M
Investigating UBE3A as a driver gene in Duplication 15q syndromeR01NS129914 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT · 2023 to 2026
$1.6M
Super Resolution STED Microscopy at UNCS10OD030300 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GUPTON, STEPHANIE · 2022 to 2022
$600k
Neural Circuit Mechanisms of Seizure Susceptibility in a Mouse Model of Angelman SyndromeF30HD111296 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nicholas W Ringelberg · 2024 to 2026
$137k
NCI NIH HHS P30 CA016086NICHD NIH HHS F30 HD111296NICHD NIH HHS P50 HD103573NIH HHS S10 OD030300NINDS NIH HHS R01 NS129914NINDS NIH HHS R01 NS131615
6 · The paper itself

Abstract

Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by loss of expression of the maternal

Indexed as

Angelman SyndromeBehavior, AnimalGABAergic NeuronsNeuronsUbiquitin-Protein LigasesAnimalsDisease Models, AnimalFemaleGlutamic AcidMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeGlutamic AcidUbe3a protein, mouseUbiquitin-Protein LigasesAngelmanbehaviormouseneurodevelopmentsleepube3a

Identifiers

PMID40935670
PMCPMC12479163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.