ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Early Life Injury Alters Spinal Astrocyte Development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neonatal injury alters synaptic transmission in the spinal superficial dorsal horn (SDH), resulting in aberrant amplification of ascending nociceptive transmission. Astrocytes orchestrate synapse development and function across the CNS and play a critical role in the emergence and maintenance of persistent pain. However, little is currently known about the postnatal development of spinal astrocytes, nor about how the maturation of SDH astrocytes is impacted by early life injury. Here, we used a hindpaw incision model of postsurgical pain in postnatal day (P) 3 mice of both sexes to elucidate the effects of neonatal injury on the maturation of SDH astrocytes. Three-dimensional morphological analysis of individual astrocytes revealed that incision elicits age-dependent changes to astrocyte structure. At P4, spinal astrocytes in incised mice show increased size and complexity compared with naive controls. This is reversed at P10 and P24, as astrocytes from incised mice are smaller and less ramified compared with their naive counterparts. Transcriptomic analysis of spinal astrocytes revealed acute changes to gene expression after neonatal injury, as 76 differentially expressed genes (DEGs) were identified at P4 (such as
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