Evidence map›Paper›PMID 40935584›Full record

Trial reportThe European respiratory journal2025

Ultrasonic elastography-guided pleural biopsy

Mingming Deng, Yang Xia, Xianwei Ye, Jiangwei Ma, Shuai Zhao, Qin Zhang, Jia Li, Jieru Lin, Anwei Jing, Zi-Yao Li and 10 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05781659 (The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of Benign and Malignant Pleural Effusion), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05781659 naunknown statusnot on this map

The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of Benign and Malignant Pleural Effusion

TypeinterventionalSponsorChina-Japan Friendship HospitalRan2023 to 2024Enrolled592ConditionsPleural EffusionArmsUltrasound elastography guided pleural biopsy, Traditional ultrasound guided pleural biopsy
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Diagnostic yield or diagnostic accuracy estimation?The European respiratory journal · 2026
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Mingming DengNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Yang XiaKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China.
Xianwei YeDepartment of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, P.R. China.
Jiangwei MaInstitute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, P.R. China.
Shuai ZhaoChina-Japan Friendship Heilongjiang Hospital, National Regional Centre for Respiratory Medicine, Harbin, P.R. China.
Qin ZhangNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Jia LiNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Jieru LinDepartment of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, P.R. China.
Anwei JingDepartment of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, P.R. China.
Zi-Yao LiDepartment of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Bin JiangDepartment of Ultrasound, The First Hospital of China Medical University, Shenyang, P.R. China.
Jie WuDepartment of Ultrasound, Guizhou Provincial People's Hospital, Guiyang, P.R. China.
Qing WenDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, P.R. China.
Jiaojiao MaDepartment of Radiology, Centre of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.
Run TongNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Ziwen ZhengNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.ORCID https://orcid.org/0000-0003-1711-6328
Weidong XuNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, P.R. China.
Felix J F HerthDepartment of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-7638-2506
Gang HouNational Centre for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China hougangcmu@163.com.ORCID https://orcid.org/0000-0003-3438-1764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditional thoracic ultrasound-guided pleural biopsy (TUSPB) is considered the initial method for histological diagnosis; however, its sensitivity for detecting malignant pleural effusion (MPE) is limited. Ultrasound elastography can be used to differentiate MPE from benign diseases by evaluating pleural stiffness. This study aimed to investigate whether ultrasonic elastography-guided pleural biopsy (UEPB) offers diagnostic accuracy superior to that of TUSPB for pleural effusions.

methodsIn this multicentre, randomised trial (ClinicalTrials.gov: NCT05781659), patients with pleural effusion of unknown origin were enrolled and randomised (1:1) to undergo either UEPB or TUSPB. The primary outcome measured was the sensitivity of UEPB in diagnosing MPE; the secondary outcomes were the diagnostic rate of the two methods in patients with different pleural thicknesses and the safety of UEPB.

resultsIn total, 232 patients with pleural effusion were enrolled, 228 of whom were included in the analysis. The sensitivity for detecting MPE was significantly greater in the UEPB group than in the TUSPB group (85.00% (51/60)

conclusionUEPB was superior to TUSPB in the diagnosis of MPE with a similar safety profile.

Indexed as

Elasticity Imaging TechniquesImage-Guided BiopsyPleuraPleural EffusionPleural Effusion, MalignantAdultAgedFemaleHumansMaleMiddle AgedSensitivity and SpecificityUltrasonography, Interventional

Identifiers

PMID40935584
PMCPMC12713391

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.