Evidence map›Paper›PMID 40935532›Full record

ArticleHarmful algae2025

First report of nodularin production by Nostochopsis sp. in a temperate eutrophic lake.

Abby M Webster, Zac Triumph, Bofan Wei, Robbie M Martin, Laura E Smith, Steven W Wilhelm, Lisa B Cleckner, N Roxanna Razavi, Gregory L Boyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Harmful algae, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abby M WebsterDepartment of Environmental Biology, State University of New York College of Environmental Science and Forestry, Syracuse, NY, USA. Electronic address: abwebste@syr.edu.
Zac TriumphDepartment of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY, USA.
Bofan WeiDepartment of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY, USA.
Robbie M MartinDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Laura E SmithDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Steven W WilhelmDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Lisa B ClecknerFinger Lakes Institute, Hobart and William Smith Colleges, Geneva, NY, USA.
N Roxanna RazaviDepartment of Environmental Biology, State University of New York College of Environmental Science and Forestry, Syracuse, NY, USA. Electronic address: razavi@esf.edu.
Gregory L BoyerDepartment of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY, USA.

Funding

The synergistic effects of climate and anthropogenic drivers on toxic cyanobacterial bloomsP01ES028939 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory James Dick, David Joseph Kennedy · 2018 to 2026
$3.7M
NIEHS NIH HHS P01 ES028939
6 · The paper itself

Abstract

Benthic cyanobacteria are understudied in comparison to their planktonic counterparts. Consequently, our understanding of cyanotoxin production in benthic mats remains limited. We detected nodularin-R (NOD-R) in a population of Nostochopsis from Honeoye Lake (New York, United States). Identification as Nostochopsis was supported by morphological (see section 3.1 for a detailed description) and metagenomic analyses. The first metagenome assembled genome of Nostochopsis was drafted and estimated at 99.28 % complete. Cyanotoxin testing of Nostochopsis biomass showed production of NOD-R but not microcystins, anatoxins, or cylindrospermopsins. The complete nodularin synthetase cluster was confirmed in the Nostochopsis genome. To our knowledge, this is the first report of nodularin production, or any cyanotoxin production, by the benthic cyanobacteria Nostochopsis. This is the fourth genus of cyanobacteria reported to produce nodularins.

Indexed as

Bacterial ToxinsCyanobacteriaHeterocyclic Compounds, 3-RingLakesPeptides, CyclicEutrophicationPhylogenyBacterial ToxinsHeterocyclic Compounds, 3-RingnodularinPeptides, CyclicBenthic cyanobacteriaCyanotoxinFreshwaterHepatotoxin

Identifiers

PMID40935532
PMCPMC12741844

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.