Trial reportJournal of clinical periodontology2025
Stability of Root Coverage Outcomes After Soft-Tissue Augmentation With a Collagen Matrix With or Without rhPDGF-BB: A 3-Year Triple-Blinded, Randomised, Placebo-Controlled Trial.
Trial report in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Stability of Root Coverage Outcomes After Soft-Tissue Augmentation With a Collagen Matrix With or Without rhPDGF-BB: A 3-Year Triple-Blinded, Randomised, Placebo-Controlled Trial.Journal of clinical periodontology · 2025Trial
- The Role of Biologically Active Materials in Peri-Implant Diseases.Journal of clinical medicine · 2026Review
- Growth factor enriched collagen matrix versus de-epithelialized graft in root coverage procedures - A randomized parallel arm clinical trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the 3-year stability of root coverage outcomes following treatment with a coronally advanced flap (CAF) and a volume-stable, cross-linked xenogeneic collagen matrix (VCMX), either soaked in recombinant human platelet-derived growth factor-BB (rhPDGF, test arm) or sterile saline (control arm).
methodsOf the original 30 participants in the triple-blind, randomised, placebo-controlled trial, 26 were available for follow-up at 1 and 3 years. The primary outcome was mean root coverage (mRC) at 3 years compared to the 6-month results. Secondary outcomes included complete root coverage, keratinised tissue width, gingival thickness, volumetric and aesthetic changes, patient-reported outcome measures (PROMs) and ultrasonographic tissue properties. Untreated contralateral teeth were also assessed.
resultsFrom 6 months to 3 years, mRC decreased by 6.7% in the control arm and 7.5% in the test arm (p > 0.05). Over 90% of treated sites maintained a stable gingival margin (≤ 0.5 mm shift). No significant inter-group differences were found for volumetric, aesthetic or PROM outcomes. Ultrasonography revealed increased tissue elasticity in treated sites. In contrast, untreated contralateral sites showed progressive gingival recession and increased hypersensitivity (p < 0.001).
conclusionBoth VCMX treatments demonstrated stable clinical and ultrasonographic outcomes over 3 years, while untreated sites showed signs of soft-tissue deterioration.
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