Evidence map›Paper›PMID 40935025›Full record

ArticleEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2025

Distinct roles of ferric carboxymaltose and ferric derisomaltose on phosphate homeostasis in iron deficiency anemia.

Jessica A Dominguez Rieg, Monika Domenech Acevedo, Jennifer Nogueira Coelho, Monica Stevens, Linto Thomas, Timo Rieg

Abstract read
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In one paragraph

Article in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Iron overload induced by ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in normal mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica A Dominguez RiegDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA; James A. Haley Veterans' Hospital, Tampa, FL 33612, USA; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33602, USA.
Monika Domenech AcevedoDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.
Jennifer Nogueira CoelhoDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.
Monica StevensDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.
Linto ThomasDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA; James A. Haley Veterans' Hospital, Tampa, FL 33612, USA.
Timo RiegDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA; James A. Haley Veterans' Hospital, Tampa, FL 33612, USA; Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33602, USA. Electronic address: trieg@usf.edu.

Funding

Research and Education in Nephrology for Undergraduate Medical Students-Florida (RENUM-FL)R25DK134324 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI Jessica A Dominguez Rieg, Timo Rieg · 2024 to 2026
$323k
BLRD VA I01 BX004968NIDDK NIH HHS R25 DK134324
6 · The paper itself

Abstract

Intravenous (IV) iron-carbohydrate nanoparticles like ferric carboxymaltose (FCM) and ferric derisomaltose (FDI) are used to treat iron deficiency anemia (IDA); however, they differ in their side-effects (e.g., hypophosphatemia). We compared the effects of FCM and FDI in a newly generated mouse model of IDA and determine their efficacy in resolving IDA and effects on mineral homeostasis. Eight-week-old female C57Bl/6J mice were fed an iron-deficient diet for 5 weeks followed by IV bleeding (0.7 % of body weight) for 3 consecutive days to establish IDA. On day 1 and 7 after induction of IDA, mice were injected with vehicle, FCM or FDI (both 20 mg kg

Indexed as

Anemia, Iron-DeficiencyFerric CompoundsMaltosePhosphatesAnimalsDisease Models, AnimalFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsHomeostasisIronMiceMice, Inbred C57BLferric carboxymaltoseFerric CompoundsFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth FactorsIronMaltosePhosphatesAnemiaDMT1Intravenous ironKidneyNpt2aPhosphate

Identifiers

PMID40935025
PMCPMC12924155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.