Evidence map›Paper›PMID 40934999›Full record

ArticleVascular pharmacology2025

The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) localize to ependymal cilia in brain ventricles.

Shahram Eisa-Beygi, Kulandaisamy Arulsamy, Kui Cui, Hao Wu, Beibei Wang, Kaifu Chen, Hong Chen

Abstract readLetter
In one paragraph

Article in Vascular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shahram Eisa-BeygiVascular Biology Program, Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA.
Kulandaisamy ArulsamyBasic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.
Kui CuiVascular Biology Program, Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA.
Hao WuVascular Biology Program, Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA.
Beibei WangVascular Biology Program, Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA.
Kaifu ChenBasic and Translational Research Division, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.
Hong ChenVascular Biology Program, Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: Hong.Chen@childrens.harvard.edu.

Funding

Molecular Regulation of AtherosclerosisR01HL146134 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2019 to 2022
$3.3M
The role of signaling adaptor protein epsin in atherosclerosisR01HL156362 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2021 to 2024
$3.1M
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in AtherosclerosisR01HL162367 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2022 to 2025
$3.0M
Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and DiseaseR01HL158097 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, CHEN, YABING · 2021 to 2024
$3.0M
Targeting Endothelial Epsins to Ameliorate Myocardial IschemiaR01HL174928 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Hong Chen, Kaifu Chen · 2024 to 2026
$2.4M
Bioinformatics Techniques to Analyze Dynamic Changes of 3D GenomeR01GM138407 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CHEN, KAIFU · 2022 to 2025
$1.8M
Novel role of Foxc2 in regulating metabolic diseaseK99HL171947 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CUI, KUI · 2024 to 2025
$251k
NHLBI NIH HHS K99 HL171947NHLBI NIH HHS R01 HL146134NHLBI NIH HHS R01 HL156362NHLBI NIH HHS R01 HL158097NHLBI NIH HHS R01 HL162367NHLBI NIH HHS R01 HL174928NIGMS NIH HHS R01 GM138407
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer's diseaseArl13bBrainCXCL12 (SDF-1)CXCR4Ependymal ciliaGPCRHydrocephalusIntraventricular hemorrhageNeurovascular diseases

Identifiers

PMID40934999
PMCPMC12988852

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.