ArticleNeurology2025
Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.European journal of neurology · 2026Article
- Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
9 authors.
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Abstract
BACKGROUND AND
objectivesHearing impairment is a major clinical issue in dementia. Acoustically altered speech (AAS) is a typical real-world listening challenge, but markers of AAS perception, especially in frontotemporal dementias (FTDs), remain undefined. We investigated whether AAS perception differentiates FTD syndromes and predicts real-world hearing symptoms.
methodsIn this cross-sectional case-control study, participants meeting diagnostic criteria for FTD and primary progressive aphasia syndromes were recruited at a UK tertiary center. Participants performed pure-tone audiometry (PTA) and 3 AAS perception tests: speech-in-babble (SIB), spectrally filtered speech (SFS), and time-compressed speech (TCS). Real-world hearing abilities were assessed through the modified Amsterdam Inventory for Auditory Disability and Handicap (mAIAD). Group characteristics were compared using analysis of variance and Fisher exact tests. Regression models adjusted for PTA and Wechsler Abbreviated Scale of Intelligence Matrices scores compared group performance on AAS tests. The Spearman test examined correlations with mAIAD scores.
resultsAmong 44 participants, the mean (SD) age was 66 (6.23) years and 13 (29.5%) were female. 29 patients with FTD (6 with nonfluent/agrammatic variant PPA [nfvPPA], 8 with semantic variant PPA [svPPA], and 15 with behavioral variant FTD [bvFTD]) were compared with 15 age-matched controls. Patients with nfvPPA had significantly higher mean PTA thresholds than controls (mean difference 12 decibels [95% CI 0.7-23.4], DISCUSSION: AAS perception stratifies FTD syndromes and constitutes a "real-world audiogram" in these diseases.
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