Evidence map›Paper›PMID 40934322›Full record

ReviewScience (New York, N.Y.)2025

Noncanonical circuits, states, and computations of the hippocampus.

Jordan S Farrell, Ivan Soltesz

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Dynamics of Dentate Gyrus Place Cells and Dentate Spikes during Spatial and Nonspatial Changes in Environments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jordan S FarrellF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-1209-5559
Ivan SolteszDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1493-3744

Funding

Molecular tools for precise manipulation of defined synaptic connectionsR01MH135934 · NIMH · STANFORD UNIVERSITY · PI Xiaoke Chen, IVAN SOLTESZ · 2024 to 2026
$4.0M
Control of Axon Initial Segment in EpilepsyR01NS121106 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA, SOLTESZ, IVAN · 2021 to 2025
$3.4M
Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the HippocampusRF1NS133381 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, SOLTESZ, IVAN · 2023 to 2023
$2.6M
Activity-dependent endocannabinoid control in epilepsyR01NS131728 · NINDS · STANFORD UNIVERSITY · PI Attila Losonczy, IVAN SOLTESZ · 2023 to 2026
$2.3M
Behavioral biomarkers for prediction of mortality and seizures in epilepsyR01NS136355 · NINDS · STANFORD UNIVERSITY · PI Sandeep R Datta, IVAN SOLTESZ · 2025 to 2026
$1.1M
Dissecting Hypothalamic Pathways for Seizure ControlR00NS126725 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Jordan Stewart Farrell · 2024 to 2026
$740k
Dissecting hypothalamic pathways for seizure controlK99NS126725 · NINDS · STANFORD UNIVERSITY · PI FARRELL, JORDAN STEWART · 2022 to 2023
$229k
NIMH NIH HHS R01 MH135934NINDS NIH HHS K99 NS126725NINDS NIH HHS R00 NS126725NINDS NIH HHS R01 NS121106NINDS NIH HHS R01 NS131728NINDS NIH HHS R01 NS136355NINDS NIH HHS RF1 NS133381
6 · The paper itself

Abstract

Traditional views of hippocampal function are largely based on the canonical flow of information from the entorhinal cortex through the trisynaptic loop-comprising the dentate gyrus and cornu ammonis regions CA3 and CA1-and back to cortex, where the hippocampus plays an important role in transforming relevant information into a usable storage system. This classic circuit has inspired current thinking on hippocampal functions related to learning, memory, and spatial navigation, but the potential functional contributions of other hippocampal areas, such as CA2, the fasciola cinereum, and the indusium griseum, and their integration of a major hypothalamic input, have been overlooked. These understudied circuits and nontraditional network dynamics such as dentate spikes have recently begun to yield fresh insights into unconventional circuit computations that extend the repertoire of hippocampal function beyond current models.

Indexed as

HippocampusNerve NetAction PotentialsAnimalsCA1 Region, HippocampalDentate GyrusEntorhinal CortexHumansHypothalamusLearningMemoryNeural Pathways

Identifiers

PMID40934322
PMCPMC12617416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.