ArticlePloS one2025
The diagnostic value of decreased levels of inflammatory markers for the state of hepatitis C virus (HCV) infection.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBlood-cell-based inflammatory biomarkers are increasingly recognized for their diagnostic value in infections due to their clinical accessibility. With Hepatitis C virus (HCV) incidence rising and its often asymptomatic onset, this study aims to improve diagnostic evidence for HCV by analyzing changes in these biomarkers.
methodsUtilizing NHANES database, we employed binary logistic regression and generalized additive models to explore the relationship between systemic inflammatory index and HCV infection. Three adjusted models controlled for confounders, and subgroup analyses were stratified by age, gender, race, and BMI.
resultsSignificant differences were observed in PLR (103.24 ± 44.59), SII (455.23 ± 339.56), PNR (58.22 ± 32.20), PMR (366.85 ± 191.76), and NMR (7.03 ± 3.78) between infected and uninfected groups (P < 0.05). Adjusted analyses revealed associations between anti-HCV and Log2-PLR (OR = 0.58), Log2-SII (OR = 0.64), Log2-PMR (OR = 0.77), and Log2-NMR (OR = 0.79). Individuals under 30 showed no significant differences. A unit increase below 9.30 in Log2-PMR reduced HCV risk by 0.60-fold. PMR demonstrated an AUC of 0.648, specificity 0.7632, and sensitivity 0.4709.
conclusionIn individuals aged 30 and above, inflammatory markers PLR, SII, PMR, and NMR decrease in HCV cases. Variability across races, genders, and BMI groups highlights their diagnostic utility in diverse populations.
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