Evidence map›Paper›PMID 40934164›Full record

ArticlePloS one2025

Happy or not? An investigative study on well-being and anhedonia in everyday life.

Sarah A Merklein, Jutta Peterburs, Annakarina Mundorf

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah A MerkleinInstitute for Systems Medicine and Department of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany.ORCID https://orcid.org/0009-0002-7952-8088
Jutta PeterbursInstitute for Systems Medicine and Department of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Annakarina MundorfInstitute for Systems Medicine and Department of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany.ORCID https://orcid.org/0000-0002-3667-5339

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anhedonia, the inability to experience pleasure or interest in activities, is a key symptom across various psychiatric disorders, including depression. It links to poor quality of life, higher suicide risk, and poorer prognosis. While anhedonia is often studied in clinical populations, its prevalence in healthy individuals and its dimensional nature remain underexplored. This study examined the prevalence of anhedonia in 128 German university students, comparing those with and without psychiatric symptoms and modeling psychiatric symptoms as predictor of anhedonia, measured with the Dimensional Anhedonia Rating Scale (DARS). Results showed that the clinical group demonstrated relatively low levels of anhedonia (total DARS-26: 85.03 ± 12.88) that did not differ from the healthy group (88.80 ± 7.88). Considerable variability suggests that a purely categorical approach to anhedonia may not capture its full complexity. Multiple regression analyses revealed that negative symptoms (e.g., affective flattening) were the strongest predictor of anhedonia, both in the full (b = -0.54, p < .001) and within the (sub-)clinical sample (b = -0.64, p < .001). Anxiety was also a significant predictor in the (sub-)clinical group (b = -1.06, p = .01), underscoring its impact on reward processing. Depression did not emerge as a strong predictor (b = -0.21, p = .49) when considered alongside other variables, indicating that its link to anhedonia may be mediated by other factors. Multigroup confirmatory factor analysis of the DARS showed that the 17-item version provided a better fit than the 26-item version, reinforcing the shorter version as a more efficient tool for assessing anhedonia. Taken together, the present findings support the use of a dimensional approach to anhedonia, which offers a more nuanced view of the underlying psychological and neurological mechanisms. Future research should explore anhedonia in larger, diverse samples for a comprehensive understanding of the link between anhedonia and mental illness. Registration: The study was pre-registered on OSF: https://doi.org/10.17605/OSF.IO/234A7.

Indexed as

AnhedoniaHappinessAdolescentAdultAnxietyDepressionFemaleGermanyHumansMalePsychiatric Status Rating ScalesQuality of LifeYoung Adult

Identifiers

PMID40934164
PMCPMC12425193

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.