Evidence map›Paper›PMID 40934104›Full record

ArticleeLife2025

Structural evolution of nitrogenase over 3 billion years.

Bruno Cuevas Zuviría, Franka Detemple, Kaustubh Amritkar, Amanda K Garcia, Lance Seefeldt, Oliver Einsle, Betül Kaçar

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruno Cuevas ZuviríaDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0003-1479-9442
Franka DetempleInstitute of Biochemistry, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0009-0000-0395-7527
Kaustubh AmritkarDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0009-0000-5270-3451
Amanda K GarciaDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.
Lance SeefeldtDepartment of Chemistry and Biochemistry, Utah State University, Logan, United States.ORCID https://orcid.org/0000-0002-6457-9504
Oliver EinsleInstitute of Biochemistry, University of Freiburg, Freiburg, Germany.
Betül KaçarDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0002-0482-2357

Funding

European Research Council 10.3030/101141673Human Frontier Science Program 10.52044/HFSP.RGY00722021.pc.gr.164263NASA 80NSSC17K0296NASA NNH23ZDA001N
6 · The paper itself

Abstract

Previously, we identified the only dinitrogen reduction mechanism known to date as an ancient feature conserved from nitrogenase ancestors, which we directly tested by resurrecting and integrating synthetic ancestral nitrogenases into the genome of

Indexed as

Azotobacter vinelandiiBacterial ProteinsEvolution, MolecularNitrogenaseModels, MolecularNitrogen FixationPhylogenyProtein ConformationBacterial ProteinsNitrogenaseancient protein reconstructionA. vinelandiievolutionary biologynitrogenaseprotein evolutionstructural reconstruction

Identifiers

PMID40934104
PMCPMC12425478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.