ArticleJournal of Alzheimer's disease : JAD2025
Linking silent pause locations in speech to amyloid and tau deposition in cognitively unimpaired individuals.
Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundConnected speech and language (CSL) analysis can differentiate typically aging individuals from those with dementia by identifying subtle changes in language-dependent measures, such as lexical diversity and fluency. Prior studies have linked features like slower speech rates and increased silent pauses with Alzheimer's disease (AD) neuropathology, but the pause patterns in preclinical AD and their syntactic locations remain unclear.ObjectiveTo investigate silent pauses as a potential early detection tool for AD in cognitively unimpaired individuals and compare their sensitivity to traditional neuropsychological tests in distinguishing biomarker-positive and biomarker-negative groups.MethodsCognitively unimpaired participants from the Wisconsin Registry for Alzheimer's Prevention with amyloid (A) and tau (T) PET imaging were included. Twenty-six participants with A+/T+ profiles were matched 1:1 with A-/T- individuals using propensity score matching for age, sex, literacy, and race (n = 52). Participants were majority female (75.6%) and non-Hispanic white (91%) with a mean (sd) age of 67.5 (6.2). CSL samples were derived from the Cookie Theft picture description task closest to PET scans. Pauses were annotated using ELAN at utterance-initial, clause-initial, and within-clause locations, with further categorization of within-clause pauses by part of speech (nouns, verbs, adjectives/adverbs). Pause rates and durations were analyzed using Mann-Whitney U tests, with effect sizes measured by Cliff's delta (δ).ResultsA+/T+ individuals had longer adjective/adverb-initial pauses than A-/T- (
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