ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025
Outcomes in uncomplicated β-hemolytic Streptococcal bloodstream infections transitioned from IV to oral antimicrobial therapy.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate clinical outcomes in patients with uncomplicated β-hemolytic Design: Retrospective cohort study. Setting: Tertiary academic hospital. Methods: This retrospective cohort study included adult patients hospitalized between 1/1/2013 and 12/31/2019 diagnosed with uBSI due to β-hemolytic streptococci. Patients were excluded if BSI was due to endovascular, central nervous system, or bone/joint infection or patient was immunosuppressed or died within 72 hours of identification of BSI. We compared outcomes including: 30-day mortality, antimicrobial therapy, BSI relapse, 30-day rehospitalization, adverse drug events, and reversion to IV therapy. Fisher's exact test was used for categorical variables; Mann - Whitney test and Independent T-test for continuous variables. Results: 232 BSIs were included. OAT was used in 152 (65%). Cohort demographics were similar. Mortality was also similar between cohorts (2% vs 6% Conclusion: For β-hemolytic
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