Evidence map›Paper›PMID 40934004›Full record

ArticleFrontiers in immunology2025

Dual diagnosis at the neuro-immune interface: a case report of neuronal intranuclear inclusion disease with acute anti-CASPR2 encephalitis.

Wan Zhu, Tiansi Liu, Xinran Yu, Min Peng, Jinghan Hu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wan Zhu *Kunming University of Science and Technology, Affiliated Hospital, People's Hospital of Wenshan Prefecture, Department of Radiology, Wenshan, China.
Tiansi Liu *Kunming University of Science and Technology, Affiliated Hospital, People's Hospital of Wenshan Prefecture, Department of Neurology, Wenshan, China.
Xinran YuKunming University of Science and Technology, Affiliated Hospital, People's Hospital of Wenshan Prefecture, Department of Radiology, Wenshan, China.
Min PengKunming University of Science and Technology, Affiliated Hospital, People's Hospital of Wenshan Prefecture, Department of Neurology, Wenshan, China.
Jinghan HuKunming University of Science and Technology, Affiliated Hospital, People's Hospital of Wenshan Prefecture, Department of Neurology, Wenshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal intranuclear inclusion disease (NIID) is a rare autosomal-dominant, progressive neurodegenerative condition characterized by complex and variable clinical manifestations that can affect multiple neurological domains. This report describes the case of a 49-year-old female patient with a 10-year history of headaches, whose older sister had been diagnosed with NIID 1 year earlier through genetic testing and a skin biopsy. Recently, the patient developed dizziness and vomiting. Although symptomatic treatment reduced incidents of vomiting, her dizziness progressively worsened. It was accompanied by lower limb weakness, gait instability, hallucinations, and abnormal sleep behaviors. Routine imaging and cerebrospinal fluid immunological and microbiological tests revealed no abnormalities. Genetic analysis revealed a 130-repeat expansion in the

Indexed as

AutoantibodiesEncephalitisIntranuclear Inclusion BodiesMembrane ProteinsNerve Tissue ProteinsNeurodegenerative DiseasesFemaleHumansMiddle AgedAutoantibodiesCNTNAP2 protein, humanMembrane ProteinsNerve Tissue Proteinsanti-CASPR2 antibody encephalitisautoimmune encephalitisMorvan syndromeneuronal intranuclear inclusion diseaseNOTCH2NLC

Identifiers

PMID40934004
PMCPMC12417165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.