Evidence map›Paper›PMID 40933967›Full record

ArticleTurkish journal of medical sciences2025

miRNA-target gene network analysis in siblings with cystic fibrosis and phenotypic variability.

Ayberk Mustafaoğlu, Senem Noyan, Yeliz Z Akkaya Ulum, Bala Gür Dedeoğlu, Nagehan Emiralioğlu, Uğur Özçelik, Ebru Yalçin, Deniz Doğru, Nural Kiper, Didem Dayangaç Erden

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Article in Turkish journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ayberk MustafaoğluFaculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0009-0004-8538-1072
Senem NoyanBiotechnology Institute, Ankara University, Ankara, Turkiye.ORCID https://orcid.org/0000-0001-6455-3702
Yeliz Z Akkaya UlumDepartment of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0003-1888-2542
Bala Gür DedeoğluBiotechnology Institute, Ankara University, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-4320-5685
Nagehan EmiralioğluDepartment of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-1405-8401
Uğur ÖzçelikDepartment of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0003-1587-5216
Ebru YalçinDepartment of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-7325-1981
Deniz DoğruDepartment of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0001-9931-9473
Nural KiperDepartment of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0003-1261-7393
Didem Dayangaç ErdenDepartment of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-0236-7565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator ( Materials and methods: Nasal cells of CF siblings from two families with discordant phenotype (n = 2 per family) were collected, and differentially expressed miRNAs were identified using miRNA arrays. Differentially expressed miRNAs and their target genes were determined using several bioinformatic databases and tools. Results: miR-449c-5p, miR-92b-3p, miR-34c-3p, miR-34c-5p, miR-6732-5p, and miR-4793-3p were differentially expressed in patients with severe disease compared to mild. Conclusion: Our results highlight the importance of miR-449c-5p interaction with

Indexed as

Cystic FibrosisGene Regulatory NetworksMicroRNAsCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansMalePhenotypeSiblingsCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorMicroRNAsCystic fibrosisgenotype phenotype correlationinflammationmiR-449c-5pphenotypic variability

Identifiers

PMID40933967
PMCPMC12419052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.