Evidence map›Paper›PMID 40933965›Full record

ArticleTurkish journal of medical sciences2025

Prognostic role of the systemic immune-inflammation index and pan-immune-inflammation value in acute methanol poisoning.

Hatice Şahin, Gülay Ulusal Okyay, Fatma Ayerden Ebinç, Fevzi Coşkun Sökmen, Emre Yaşar, Gülşen Akçay, Mehmet Deniz Ayli

Abstract read
In one paragraph

Article in Turkish journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hatice ŞahinDivision of Nephrology, Department of Internal Medicine, Etlik City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-7146-4828
Gülay Ulusal OkyayDivision of Nephrology, Department of Internal Medicine, Etlik City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0003-0770-1283
Fatma Ayerden EbinçDivision of Nephrology, Department of Internal Medicine, Etlik City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-7893-3498
Fevzi Coşkun SökmenDepartment of Internal Medicine, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-5621-8274
Emre YaşarDivision of Nephrology, Department of Internal Medicine, Etlik City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0001-8271-1831
Gülşen AkçayDepartment of Emergency Medicine, Etlik City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0001-8377-5239
Mehmet Deniz AyliDivision of Nephrology, Department of Internal Medicine, Etlik City Hospital, Ankara, Turkiye.ORCID https://orcid.org/0000-0003-3145-1595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the systemic immune-inflammation index (SII) and the pan-immune-inflammation value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP. Material and methods: This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, Türkiye: University of Health Sciences Dışkapı Yıldırım Beyazıt Education and Research Hospital (1 January 2015 to 1 October 2022) and Etlik City Hospital (1 October 2022 to 11 March 2025). Demographic, clinical, and laboratory data, along with treatment details and outcomes (discharge or inhospital death), were systematically recorded. Results: A total of 76 patients were included, of whom 92.1% were male, with a mean age of 49.0 ± 12.4 years. During hospitalization, 48.6% (n = 37) died. Both SII and PIV values at admission were significantly higher in nonsurvivors (p < 0.001 for SII; p = 0.031 for PIV). In multivariate Cox regression analysis, higher SII (HR: 2.44; 95% CI: 1.05-5.67; p = 0.034) and PIV (HR: 2.08; 95% CI: 1.05-4.13; p = 0.030) were independently associated with increased risk of mortality. Receiver operating characteristic (ROC) analysis showed an AUC of 0.750 (95% CI: 0.649-0.865) for SII, with an optimal cutoff of 665.6 (sensitivity: 50%; specificity: 46%), and an AUC of 0.640 (95% CI: 0.519-0.769) for PIV, with an optimal cutoff of 512.5 (sensitivity: 53%; specificity: 47%). Conclusion: SII and PIV measured at hospital admission may have potential prognostic value in predicting inhospital mortality in patients with acute MP.

Indexed as

InflammationMethanolPoisoningAcute DiseaseAdultBiomarkersFemaleHospital MortalityHumansMaleMiddle AgedPrognosisRetrospective StudiesROC CurveTurkeyBiomarkersMethanolInflammationmethanolmortalitypoisoning

Identifiers

PMID40933965
PMCPMC12419055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.