Evidence map›Paper›PMID 40933958›Full record

ReviewThe World Allergy Organization journal2025

Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.

Steering Committee Authors, M Pilar Berges-Gimeno, Emilio Alvarez-Cuesta, Marina Atanaskovic-Markovic, Marina Attanassi, Carlo Caffareli, Jean-Christoph Caubet, George du Toit, Antonieta Guzman-Melendez, Semanur Kuyucu and 39 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The World Allergy Organization journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Steering Committee Authors
M Pilar Berges-GimenoDepartment of Allergy, Hospital Universitario Ramón y Cajal, Spain.
Emilio Alvarez-CuestaAcademic in Allergy and Immunology, Allergy Division, Former Head, Ramon & Cajal University Hospital, Madrid, Spain.
Marina Atanaskovic-MarkovicDepartment of Allergology and Pulmonology, University Children's Hospital, Belgrade, Serbia.
Marina AttanassiDepartment of Pediatrics, University of Chieti, Chieti, Italy.
Carlo CaffareliClinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy.
Jean-Christoph CaubetPediatric Allergy Unit, Department of Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland.
George du ToitDepartment of Paediatric Allergy, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Antonieta Guzman-MelendezSection of Immunology, HIV and Allergy, Department of Medicine, Clinical Hospital University of Chile, Chile.
Semanur KuyucuDepartment of Paediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Ricardo Madrigal-BurgaletaAllergy & Severe Asthma Service, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Lina MayorgaAllergy Unit and Research Group, Hospital Regional Universitario de Málaga, UMA-IBIMA-BIONAND, ARADyAL, Málaga, Spain.
Elizabeth PowellDepartment of Paediatric Allergy, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Michelle RamienDepartment of Pediatrics, University of Calgary, Alberta Children's Hospital, Calgary, Canada.
Eva Rebelo GomesAllergy and Clinical Immunology Department, Centro Hospitalar Universitário Santo António, Porto, Portugal.
Francesca MoriAllergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Andrew A WhiteDivision of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, California, USA.
Ignacio J AnsoteguiHospital Quironsalud, Bizkaia, Bilbao-Erandio, Spain.
Review Panel Authors
Marcelo Vivolo AunFaculdade Israelita de Ciências da Saúde Albert Einstein School of Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Annick BarbaudSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP Sorbonne Université, Hôpital Tenon, Département de dermatologie et allergologie, Paris, France.
Sevim BavbekDivision of Immunology and Allergy, Department of Chest Diseases, School of Medicine, Ankara University, Ankara, Turkey.
Lorena Bernal-RubioDepartment of Allergy, Hospital Universitario Ramón y Cajal, Spain.
Knut BrockowDepartment of Dermatology and Allergy Biederstein, Technical University of Munich, Faculty of Medicine and Health, Munich, Germany.
Lucrecia BustamanteHospital Italiano of Buenos Aires, Argentina.
Yoon-Seok ChangDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Luis Felipe Chiaverini EnsinaDivision of Allergy, Clinical Immunology and Rheumatology, Department of Paediatrics, Federal University of São Paulo, Brazil.
Javier Cuesta-HerranzDepartment of Allergy and Immunology, IIS-Fundación Jiménez Díaz UAM, Spain.
Bryan N FernandesAllergy & Severe Asthma Service, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Lene Heise GarveyAllergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Pedro Giavina-BianchiUniversity of São Paulo, Brazil.
Mona I KidonDepartment of Pediatrics, Faculty of Medical & Health Sciences, Tel Aviv University and Sheba Medical Center, Israel.
Marina Labella AlvarezHospital Regional Universitario de Málaga, Spain.
Joanna S MakowskaDepartment of Rheumatology, University of Lodz, Poland.
Susana MarinhoAllergy Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust and the University of Manchester, Manchester, UK.
David Alejandro Mendoza-HernándezInstituto Nacional de Pediatría, Mexico City, Mexico.
Mauro PaganiASST Mantova, Italy.
Valeria Palma PinoClinical Hospital, University of Chile, Santiago, Chile.
Claudio A S ParisiHospital Italiano de Buenos Aires, Argentina.
Hae-Sim ParkDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, South Korea.
Jonathan PeterDivision of Allergology, University of Cape Town, South Africa.
Elizabeth J PhillipsCenter for Drug Safety and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Kimberly RismaDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Emilio Solano-SolaresDepartment of Allergy, Ramón y Cajal University Hospital, Madrid, Spain.
Luciana Kase TannoDivision of Allergy, Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France.
Rocco Luigi ValluzziTranslational Research in Pediatric Specialties Area, Division of Allergy, Bambibno Gesù Children's Hospital, IRCCS, Rome, Italy.
Paula Vazquez-RevueltaDrug Desensitization Center, Catalan Institute of Oncology, Barcelona, Spain.
Timothy J WattsDepartment of Respiratory Medicine & Allergy, Homerton Healthcare NHS Foundation Trust, London, UK.
Masao YamaguchiDivision of Respiratory Medicine, Third Department of Medicine, Teikyo University Chiba Medical Center, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug hypersensitivity reactions (DHRs) in children and adolescents are less common than in adults but can have serious consequences if mismanaged. Mislabeling children as drug-allergic due to incomplete diagnostic evaluations leads to unnecessary medication restrictions, increased healthcare costs, and suboptimal treatment choices. This Statement from the World Allergy Organization (WAO) provides evidence-based recommendations for evaluating and managing pediatric DHRs, emphasizing accurate diagnosis through

Identifiers

PMID40933958
PMCPMC12419032

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