Potential protective regulatory effects on radiation-induced esophageal injury in TUT4

Huiwen Ren, Wei Li, Zhigang Fan, Jianlin Wang, Zhiqiang Sun, Renhua Huang, Judong Luo, Bo Gao

Abstract read

In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huiwen Ren *Department of Radiotherapy, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Wei Li *Clinical Nutrition Department of The Tenth People's Hospital, Tongji University, Shanghai, China.

Zhigang Fan *Department of Oncology, 3201 Hospital of Xi'an Jiaotong University Health Science Center, Shanghai, China.

Jianlin WangDepartment of Radiotherapy, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China.

Zhiqiang SunDepartment of Radiotherapy, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China.

Renhua HuangDepartment of Radiation, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Judong LuoDepartment of Radiotherapy, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Bo GaoDepartment of Rheumatology and Immunology, The Second People's Hospital of Changzhou, the Third Affilitated Hosptial of Nanjing Medical University, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Terminal uridyl transferase 4 (TUT4), a nucleotide transferase that modifies miRNA sequences, plays a critical role in regulating miRNA target interactions and function. However, its involvement in radiation-induced esophageal injury remains poorly understood. Methods: To investigate this, we performed computational analysis of RNA-seq data from irradiated esophageal tissues of wild-type and TUT4-knockout (TUT4 Results: Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these DEmRNAs were significantly associated with biological processes including lipid metabolism, fatty acid metabolism, proteolysis, and broader metabolic functions. Notably, DEmRNAs in TUT4

Indexed as

esophageal tissueradiation-induced esophageal injuryradioactivityradioprotectionTUT4

Identifiers

PMID40933885

DOI10.3389/fonc.2025.1600597

PMCPMC12417170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.