ReviewAnimal reproduction2025
Metabolic and endocrinologic interplay in the peri-ovulatory follicle to support the cumulus-oocyte-complex towards full competence.
Review in Animal reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Development and maturation of canine oocytes: roles of ovarian and oviductal environment in the acquisition of developmental competence.The Journal of reproduction and development · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increase in free fatty acid (FFA) levels in the circulation and follicular fluid in response to the negative energy balance of dairy cows has received significant attention during the last decades. However, until recently the potential effect of FFA on the periovulatory steroid environment has been overlooked. The well-orchestrated luteinizing hormone (LH) peak induces a steroid shift in the periovulatory follicle, from Estradiol-17β (E2) dominance around the LH peak towards progesterone (P4) dominance around ovulation, and is a prerequisite for optimal cytoplasmic and nuclear maturation in the oocyte and oocyte developmental competence. Recent insights in literature demonstrate a link between saturated and mono-unsaturated FFAs and the expression of gonadotrophin receptors, follicle stimulating hormone (FSH)R and LHR, including steroid related enzymes and E2 synthesis by in vitro granulosa cells. The current review will focus on the potential role of mono-unsaturated oleic acid, the most abundant FFA in follicular fluid, on steroidogenesis and its potential effect on the cumulus-oocyte-complex (COC) during final maturation. The data of this review suggest the potential for a regulatory interlinked system, which includes the oocyte secreted factor FGF10 and oleic acid, that modulates the steroidogenic switch from E2 to P4 in the periovulatory follicle, via actions that involve the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in support of the delicate and well-orchestrated dialogue between the oocyte and cumulus cells during final maturation of COCs.
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Registered trials
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