Evidence map›Paper›PMID 40933845›Full record

SynthesisFrontiers in oral health2025

Key virulence genes associated with

Dinda Kurnia Fitri, Nozimjon Tuygunov, Wan Himratul Aznita Wan Harun, Isty Adhitya Purwasena, Arief Cahyanto, Myrna Nurlatifah Zakaria

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. α2-3-Sialylated Glycoproteins AttenuateInternational journal of molecular sciences · 2026
    Article
  5. Identification ofMicroorganisms · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Capsaicin inhibits cariogenicJournal of oral microbiology · 2026
    Article
  11. Synergistic inhibition ofFrontiers in microbiology · 2026
    Article
  12. Article
  13. Article
  14. OralFrontiers in dental medicine · 2025
    Article
  15. Relative stability ofJournal of oral biology and craniofacial research
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dinda Kurnia FitriDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
Nozimjon TuygunovFaculty of Dentistry, Kimyo International University in Tashkent, Tashkent, Uzbekistan.
Wan Himratul Aznita Wan HarunDepartment of Oral & Craniofacial Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
Isty Adhitya PurwasenaDepartment of Microbiology, School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung, Indonesia.
Arief CahyantoDepartment of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Myrna Nurlatifah ZakariaDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: A comprehensive search of PubMed, Scopus, and Web of Science was conducted in accordance with PRISMA guidelines. Studies investigating the genetic and regulatory mechanisms of biofilm formation, as well as the effects of experimental treatments, were included, and the risk of bias was assessed using the QUIN tool. Results: Key virulence genes were identified, including glucosyltransferases Conclusion: While key virulence genes have been well characterized, further research is needed to clarify how their regulation is influenced by environmental conditions. Insights from this review may support the development of novel therapeutic approaches that reduce Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024577977, PROSPERO CRD42024577977.

Indexed as

biofilm formationdental cariesdental plaqueglucosyltransferaseStreptococcus mutansvirulence genes

Identifiers

PMID40933845
PMCPMC12417473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.