ArticleFrontiers in aging neuroscience2025
Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Investigation of the effects of different rehabilitation approaches in elderly individuals with mild cognitive impairment.BMC geriatrics · 2026Trial
- Quantifying Dexterity and Grip Strength Associations between Age, Cognitive Function (MoCA), and Cerebellar Gray Matter Volume in Healthy Adults across the Adult Lifespan.Research square · 2026Article
- Tactile sensation moderates the association between hand dexterity and higher-level cognition in older adults with and without MCI.Frontiers in aging neuroscience · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Motor function is a sensitive indicator of cognitive aging but the unique contributions of different motor domains are unclear when assessed together. Methods: We evaluated 98 community-dwelling older adults (median age: 74). From a neuropsychological battery, a primary Global Cognitive Composite score (GCCS) and three secondary domain scores were derived using Principal Component Analysis (PCA). Motor predictors included the Nine-Hole Peg Test (NHPT), grip strength, Apraxia Screen of TULIA (AST), SPPB sub-tests (5-chair-rises time (5CRT), 4 m-walk time (4MWT), balance), and inertial measurement unit (IMU)-based gait parameters. Stepwise regression controlling for age and sex identified robust predictors of the GCCS. Results: The final model identified several significant, independent motor predictors of the GCCS. Poorer hand dexterity (NHPT; Conclusion: Hand dexterity (NHPT) and specific functional mobility tasks (5CRT, 4MWT) are robust, independent predictors of cognition in older adults. Grip strength, balance, usual gait speed, and gait variability offer limited additional value when assessed together. The NHPT and timed SPPB components are accessible, pragmatic tools for motor-cognitive research and screening.
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