Evidence map›Paper›PMID 40933822›Full record

ArticleFrontiers in aging neuroscience2025

The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity.

Ming Zhao, Jiayue Zhang, Qianqian Yang, Lei Chen, Hongjian Shen, Yingyan Pu, Wei Wei, Yi Han, Ping Zhang

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In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ming Zhao *Department of Neurology, Naval Medical Center of PLA, Naval Medical University, Shanghai, China.
Jiayue Zhang *Department of Neurology, Shenzhen Samii International Medical Center (The Fourth People's Hospital of Shenzhen), Shenzhen, China.
Qianqian Yang *Department of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai, China.
Lei ChenDepartment of Cerebrovascular Disease Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Hongjian ShenDepartment of Cerebrovascular Disease Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yingyan PuInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of the Ministry of Education and the Collaborative Innovation Center for Brain Science, Naval Medical University, Shanghai, China.
Wei WeiDepartment of Neurology, Naval Medical Center of PLA, Naval Medical University, Shanghai, China.
Yi HanDepartment of Neurology, Naval Medical Center of PLA, Naval Medical University, Shanghai, China.
Ping ZhangDepartment of Neurology, Naval Medical Center of PLA, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase (MATK) in CCH patients with WMH. Methods: We recruited 42 anterior circulation stenosis patients with CCH and WMH (CCH-WMH group) and 45 age-matched healthy controls. MATK mRNA expression in peripheral blood mononuclear cells (PBMCs) was quantified using qPCR. WMH severity was graded using the Fazekas scale. Correlations between MATK expression and imaging/clinical parameters were analyzed using Pearson's correlation and logistic regression. Diagnostic performance was assessed via ROC analysis. Results: Megakaryocyte-associated tyrosine kinase expression was significantly downregulated in the CCH-WMH group versus controls (1.20 ± 0.99 vs. 1.84 ± 0.87; Conclusion: Reduced peripheral MATK expression correlates with WMH severity in CCH patients and may serve as a potential diagnostic biomarker.

Indexed as

chronic cerebral hypoperfusionmagnetic resonance imagingMATKvascular cogitive impairmentwhite matter hyperintensity

Identifiers

PMID40933822
PMCPMC12417534

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