Evidence map›Paper›PMID 40933799›Full record

ArticleSurgery open science2025

Feasibility of intraluminal oxygen delivery after minimally invasive esophagus resection.

Douwe van der Steen, Anne M Leferink, Frederieke A Dijkstra, Boudewijn van Etten, Eric Keus, Rutger J Spruit, Roy J J Verhage, Jeroen J Kolkman, Jan Willem Haveman

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Article in Surgery open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Douwe van der SteenDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Anne M LeferinkFaculty of Science and Technology, University of Twente, Enschede, the Netherlands.
Frederieke A DijkstraDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Boudewijn van EttenDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Eric KeusDepartment of Intensive Care Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Rutger J SpruitDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Roy J J VerhageDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Jeroen J KolkmanDepartment of gastroenterology and hepatology, Medisch Spectrum Twente, Enschede, the Netherlands.
Jan Willem HavemanDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Anastomotic leakage (AL) is a severe complication after esophagectomy. Intraluminal oxygen delivery at the anastomosis site might improve the viability of the tissue and thereby reduce the incidence of AL. We present a feasibility study of intraluminal oxygen delivery after esophagectomy. Methods: Eighteen patients scheduled for robot-assisted minimally invasive esophagectomy with an intrathoracic anastomosis were selected to receive an additional manometry catheter for intraluminal oxygen delivery at the anastomosis site. The primary endpoint was the feasibility of placing the catheter in the correct position and staying in situ for five days postoperatively. Intraluminal pressure was monitored during oxygen delivery at flow rates of 0 (control group), 1, 2, or 4 ml/min. Patients were questioned on the comfort of the catheter. Results: In two patients, intraoperative placement of the catheter was unsuccessful. Two others replaced these patients according to the study protocol. 16 patients were analyzed. In five patients, the catheter was accidentally removed before the end of the study. The primary endpoint was successful in 11/16 patients (69 %). Intraluminal pressure in the 1 ml/min group did not differ from the control group. Intraluminal pressure in the 2 ml/min group increased substantially compared to the control group. Patients reported comfort rates that decreased over time. Conclusion: This study shows that it is feasible to administer intraluminal oxygen in the first five days after esophagectomy and that a flow rate of 1 ml/min is not associated with increased intraluminal pressure. Future studies are required to study the effectiveness of intraluminal oxygen delivery in preventing AL.

Indexed as

Anastomotic leakageComplication reductionEsophagus resection

Identifiers

PMID40933799
PMCPMC12418989

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