ArticleFrontiers in pediatrics2025
Anxiety and depression in pediatric patients with disorder of brain-gut interaction: the role of diarrhea and abdominal pain as key determinants.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children.Children (Basel, Switzerland) · 2026Article
- A critical appraisal of integrating family constellation therapy with pharmacological treatment for depression.Frontiers in psychiatry · 2026Review
- Herbal hot compress combined with bianstone warm ironing improves anxiety and cognitive impairment via gut-brain-HPA axis in pubertal mesenteric lymphadenitis rats.Frontiers in pediatrics · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
Objective: This study aimed to evaluate the prevalence of anxiety and depression in children diagnosed with disorder of brain-gut interaction (DGBI) and to examine their association with abdominal pain and diarrhea. Methods: This study employed a mixed-methods design, combining cross-sectional surveys with longitudinal follow-up, enrolling 311 children aged 6-18 years, including 119 in the DGBI group and 192 in the non-DGBI group. Psychological status was assessed using the Screen for Child Anxiety-Related Emotional Disorders (SCARED) and the Children's Depression Inventory-Second Edition (CDI-2). Symptom diaries were utilized to document abdominal pain intensity (measured via Visual Analog Scale, VAS) and diarrhea frequency. Multivariate logistic regression analysis was performed to identify significant risk factors. Results: The DGBI group exhibited significantly higher prevalence rates of anxiety (40.3% vs. 16.7%, Conclusion: DGBI are strongly associated with elevated rates of anxiety and depression in pediatric populations, with abdominal pain and diarrhea serving as critical symptomatic drivers. Family support emerged as a protective factor against depression. These findings underscore the importance of routine psychological screening and the implementation of integrated, multidisciplinary interventions in the clinical management of DGBI.
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