Evidence map›Paper›PMID 40933703›Full record

ArticleFrontiers in pediatrics2025

Jan Heyer, Stella Volmering, Camila Hoyos-Banchon, Sarah Koc, Lydia Jeremiah, Ulrich Steinseifer, Thorsten Orlikowsky, Sebastian V Jansen, Johanna C Clauser, Mark Schoberer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Reperfused human umbilical cords: hydrodynamic and hemolytic analysis of theFrontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jan HeyerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Stella VolmeringDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Camila Hoyos-BanchonDepartment of Pediatric and Adolescent Medicine, Neonatology, Medical Faculty, University Hospital RWTH Aachen, Aachen, Germany.
Sarah KocDepartment of Pediatric and Adolescent Medicine, Neonatology, Medical Faculty, University Hospital RWTH Aachen, Aachen, Germany.
Lydia JeremiahDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Ulrich SteinseiferDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Thorsten OrlikowskyDepartment of Pediatric and Adolescent Medicine, Neonatology, Medical Faculty, University Hospital RWTH Aachen, Aachen, Germany.
Sebastian V JansenDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Johanna C ClauserDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Mark SchobererDepartment of Pediatric and Adolescent Medicine, Neonatology, Medical Faculty, University Hospital RWTH Aachen, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hemolysis is a relevant complication and is responsible for morbidity and mortality of neonatal extracorporeal membrane oxygenation (ECMO) therapy. For novel therapies like artificial placenta, hemolysis could also lead to complications or therapy failure, especially since the targeted patients are born at the borderline of viability. Standardized Methods: Human neonatal blood was harvested from placentas and umbilical cords of neonates born by cesarean section. Porcine blood was obtained from a local abattoir. Both collection processes followed predefined standardized protocols. Normalized Index for hemolysis (NIH) was calculated based on determined free plasma hemoglobin. Result: There was a significantly ( Discussion: In standardized

Indexed as

artificial placentaneonatal blood hemolysisneonatal ECMOporcine vs. neonatal bloodpreterm infants

Identifiers

PMID40933703
PMCPMC12417390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.