ArticleResearch in pharmaceutical sciences2025
Development and evaluation of gelatin/hyaluronic acid nanofibrous dressing loaded with silver nanoparticles and phenytoin for enhanced wound healing: an
Article in Research in pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Phytoextract-loaded bioinspired PLGA nanofibrous scaffold promotes diabetic wound healing via anti-inflammatory and antioxidant effects in in vitro and in vivo experimental models.Journal of molecular histology · 2026Article
- Biopolymer-Based Electrospun Nanofibers for Wound Healing, Regeneration, and Therapeutics.Materials (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Wound dressings are essential in managing chronic wounds like pressure ulcers, which increase healthcare costs and hospital stays. There is a rising demand for advanced dressings that effectively promote healing. This study developed electrospun gelatin-hyaluronic acid (Gel/HA) nanofibers loaded with silver nanoparticles (Ag NPs) and phenytoin to enhance wound healing. Experimental approach: Ag NPs were synthesized via silver nitrate reduction using trisodium citrate and tannic acid, and characterized for size, zeta potential, PDI, UV-Vis absorption, and XRD patterns. Drug-free and drug-loaded Gel/HA nanofibers were fabricated and analyzed using FE-SEM, FTIR, DSC, XRD, swelling behavior, drug loading, and release profiles. In vitro antibacterial and in vivo wound healing studies were conducted. Findings/Results: Optimized Ag NPs had a size of 41.96 ± 1.2 nm, zeta potential of -23.77 ± 1.31 mV, and PDI of 0.35 ± 0.02. The ideal nanofiber formulation (20 g Gel and 0.25 g HA/100 mL) showed drug loading efficiencies of 56.02 ± 1.8% (Ag NPs) and 61.02 ± 2.82% (phenytoin), with release times of 22.23 and 28.53 h, respectively. The nanofibers demonstrated high swelling (822.2%) and strong antibacterial activity. In vivo studies revealed significantly faster wound closure, improved epithelialization, collagen deposition, and complete healing within 15 days. These effects reflect the synergy between Ag NPs' antimicrobial and phenytoin's regenerative properties. Conclusion and implications: Gel/HA nanofibers loaded with Ag NPs and phenytoin show great promise as advanced wound dressings. Further studies in larger animal models and clinical trials are warranted.
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Registered trials
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