ArticleFrontiers in medicine2025
Differences in macular structure and microvasculature between high myopia and non-high myopia.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.BMC ophthalmology · 2026Article
- Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.Frontiers in cell and developmental biology · 2026Article
- Ultra-widefield swept-source OCT angiography assessment of choroidal changes in Chinese myopic adults.Frontiers in medicine · 2026Article
- Quantitative color fundus photography parameters as potential biomarkers of axial length progression: evidence from a machine learning cohort study.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the retinal and choroidal morphological and microvascular changes in myopic eyes using optical coherence tomography angiography (OCTA). Methods: In this retrospective, cross-sectional study, 142 eyes from 84 myopic patients were categorized into two groups based on spherical equivalent (SE): high myopia (HM; SE ≤ -6.0 D, 72 eyes) and non-high myopia (NHM; -6.0 D < SE ≤ -0.5 D, 70 eyes) groups. OCTA-derived parameters, including foveal retinal thickness (RT), choroidal thickness (CT), superficial retinal vessel density (SRVD) and deep retinal vessel density (DRVD), choriocapillaris density (CCD), and foveal avascular zone (FAZ) area and perimeter, were analyzed. Results: The mean SE was -10.16 ± 3.55 D in the HM group and -3.86 ± 1.60 D in the NHM group. RT measurements revealed substantial increases in HM eyes, including total foveal (276.4 ± 36.1 μm vs. 250.1 ± 23.3 μm; Conclusion: High myopia is associated with distinct retinal and choroidal alterations, including increased RT, reduced CT and CCD, and enlarged FAZ, suggesting progressive microvascular and structural remodeling with myopia severity.
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