Evidence map›Paper›PMID 40933508›Full record

ArticleJournal of addiction psychiatry2025

Precision Genomics: A Reality Having Universal Impact in a New Era of Psychiatry - Lessons Learned, Past and Present.

Kenneth Blum, Alireza Sharafshah, Jag Khalsa, Kai Uwe-Lewandrowski, Kavya Mohankumar, Panayotis K Thanos, Albert Pinhasov, David Baron, Catherine A Dennen, Joseph J Morgan and 29 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of addiction psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Kenneth BlumDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
Alireza SharafshahCellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Jag KhalsaDepartment of Medicine, School of Medicine, University of Maryland, Baltimore, USA.
Kai Uwe-LewandrowskiDivision of Personalized Pain Therapy Research & Education, Center for Advanced Spine Care of Southern Arizona, Tucson, USA.
Kavya MohankumarDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Panayotis K ThanosDepartment of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, USA.
Albert PinhasovDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
David BaronDivision of Addiction Research & Education, Center for Sports, Exercise, and Mental Health, Western University of Health Sciences, Pomona, USA.
Catherine A DennenDepartment of Family Medicine, Jefferson Health Northeast, Philadelphia, USA.
Joseph J MorganSubstance Use Disorders Institute University of Sciences, Philadelphia, USA.
Marco LindenauDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Igor ElmanDepartment of Psychiatry and Cambridge Health Alliance, Harvard Medical School, Cambridge, USA.
Eliot L GardnerDepartment of Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, USA.
Mark S GoldDepartment of Psychiatry, Washington University School of Medicine, USA.
Edward J ModestinoDepartment of Psychology, Curry College, Milton, USA.
Fuehrlein BrianDepartment of Psychiatry, Yale University, New Haven, USA.
Paul R CarneyDivision Pediatric Neurology, School of Medicine, University of Missouri, Columbia, USA.
Rene CorteseDepartment of Child Health, Child Health Research Institute, School of Medicine, University of Missouri, Columbia, USA.
Abdalla BowirratDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
Margaret A MadiganDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Keerthy SunderDepartment of Medicine, Riverside School of Medicine, University of California, Riverside, USA.
Morgan P LorioOrlando College of Osteopathic Medicine (OCOM), Orlando, USA.
Foojan ZeineAwareness Integration Institute, San Clemente, USA.
Nicole JafariDivision of Personalized Medicine, Global Growth Institute, Inc., San Clemente, USA.
Milan T MakaleDepartment of Radiation Oncology, University of California San Diego, La Jolla, USA.
Debasis BagchiDepartment of Pharmaceutical Sciences, Texas Southern University College of Pharmacy, Houston, USA.
Mauro CeccantiAlcohol Addiction Program, Latium Region Referral Center, Sapienza University of Rome, Roma, Italy.
Rossano K A FiorelliDepartment of General and Specialized Surgery, Gaffrée e Guinle Universitary Hospital (EBSERH), Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil.
Sérgio Luís SchimidtGraduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Daniel SippleM Health Fairview University of Minnesota Medical Center, Minneapolis, USA.
Alexander P L LewandrowskiDornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, USA.
Gianni MatareDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Shaurya MahajanDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Yatharth MahajanDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Colin HannaDepartment of Psychology, University South Dakota, Vermillion, USA.
Daniel GasteluDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Anand SwaroopDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Chynna FliegelmanDivision of Clinical Neurology, The Blum Institute of Neurogenetics & Behavior, Austin, USA.
Rajendra D BadgaiyanDepartment of Psychiatry, Texas Tech University Health Sciences, Lubbock, USA.

Funding

Prenatal Tobacco and Cannabis Exposure: A Translational StudyR33DA045640 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D, THANOS, PANAYOTIS K · 2021 to 2023
$999k
Prenatal Tobacco and Cannabis Exposure: A Translational StudyR21DA045640 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D, THANOS, PANAYOTIS K · 2018 to 2019
$434k
A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use DisorderR41MD012318 · NIMHD · VERSA INTEGRATED SOLUTIONS, INC. · PI BLUM, KENNETH, GONDRE-LEWIS, MARJORIE C · 2017 to 2017
$221k
CSRD VA I01 CX000479CSRD VA I01 CX002099NIDA NIH HHS R21 DA045640NIDA NIH HHS R33 DA045640NIMHD NIH HHS R41 MD012318
6 · The paper itself

Abstract

Addiction neuroscience explores the complex interplay between genetic, neurobiological, environmental, and socio-spiritual factors underlying substance and behavioral addictions. Over the past three decades, research in this domain has identified critical molecular and epigenetic mechanisms-particularly those affecting dopaminergic signaling and reward pathways-that contribute to both vulnerability and resilience to addictive behaviors. Central to this understanding is the concept of reward deficiency syndrome (RDS), first introduced by Kenneth Blum, which posits that hypodopaminergic functioning predisposes individuals to seek maladaptive rewards. Advances in neurogenetics, including the identification of key polymorphisms such as the DRD2 A1 allele, have paved the way for precision tools like the genetic addiction risk severity (GARS

Indexed as

DisorderGenomicsPsychiatrySyndrome

Identifiers

PMID40933508
PMCPMC12419148

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.