Sensitization to common food allergens in infants with food protein-induced allergic proctocolitis: A prospective study.

Background: Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-associated disease, although some evidence exhibits IgE sensitization in a minority of patients. Objectives: This study aimed to determine the prevalence of IgE sensitization to common foods using skin tests and assess milk outgrowing in infants with FPIAP over a 5-year follow-up period. Methods: This prospective study included infants with FPIAP in 2017. Skin prick tests were done using commercial extracts of 11 common food allergens. Infants were followed for 5 years, and the resolution was established by successfully ingesting cow's milk. Results: Of 126 infants analyzed, 81 infants (40 boys and 41 girls) with FPIAP completed this study. The frequency of food sensitization was 32% to at least one of the applied food allergens. Cow's milk (13.6%), egg (13.6%), and beef (6.2%) were the most frequent allergens, respectively. In this study, 45.7% of the infants developed a tolerance to the milk by the age of 1 year, 77.1% by the age of 2, 91.3% by the age of 3, and 96.3% by the age of 4. The rate of sensitization to milk was significantly different based on the tolerance time of early onset and grated late start for cow's milk ( Conclusion: This study suggests pointing out skin tests of infants with FPIAP for common food allergens because IgE-mediated sensitization can infer a greater chance of a persistent course of milk intolerance.