Evidence map›Paper›PMID 40933400›Full record

ArticleFrontiers in public health2025

Global trends and health inequalities in mental disorders among older adults: a comprehensive analysis using global burden of disease 2021 data.

Ying Chen, Xiao Dong, Wenxing Xu, Yudan Long, Kai Liu

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Association Between Self-Reported Psychiatric Diseases and Oral Health Among Older Adults.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying Chen *Medical Laboratory Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China.
Xiao Dong *Geriatric Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China.
Wenxing Xu *Geriatric Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China.
Yudan Long *Hainan Medical University, Haikou, Hainan, China.
Kai LiuGeriatric Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to analyze global trends and health inequalities in mental disorders among older adults (≥60 years) using Global Burden of Disease (GBD) 2021 data, with a focus on informing equity-focused public health strategies to address disparities in burden and access to care. Methods: Using GBD 2021 data, we examined mental disorders in adults ≥60 across 204 countries (1990-2021). We calculated age-standardized incidence (ASIR) and disability-adjusted life years (DALYs) rates and estimated annual percentage change (EAPC). Bayesian Age-Period-Cohort modeling and frontier analysis assessed trends and projections. Analyses used R (v4.4.2) and JD_GBDR software. Findings: In 2021, there were 74.9 million (95%UI: 59.8-94.2) new mental disorder cases among older adults globally, with an ASIR of 6,867.6 per 100,000. ASIR remained stable since 1990 (EAPC: 0.01), but varied regionally from 13,024.1 (Central Sub-Saharan Africa) to 4,643.9 (Oceania). The age-standardized DALY rate (ASDR) was 2,095.4 per 100,000, highest in low-SDI regions (2,423.9) and lowest in high-SDI regions (1,934.2). Females had higher ASIR (7,483.7 vs. 5,181.6) and ASDR (2,198.3 vs. 1,760.2) than males, with male DALYs increasing (EAPC: 0.07). By 2035, ASDR is projected to rise to 2,494.5, with depressive and anxiety disorders predominant in high-SDI regions and schizophrenia more prevalent in low-SDI areas. Conclusion: Significant disparities persist, with low-SDI regions and women disproportionately affected. Targeted strategies should strengthen mental healthcare access, implement sex-specific interventions, and address aging-related challenges.

Indexed as

Global Burden of DiseaseGlobal HealthHealth Status DisparitiesMental DisordersAgedAged, 80 and overBayes TheoremDisability-Adjusted Life YearsFemaleHumansIncidenceMaleMiddle Ageddisability-adjusted life years (DALYs)geriatric mental healthglobal burden of diseasehealth inequalitiessocio-demographic index (SDI)

Identifiers

PMID40933400
PMCPMC12419478

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.