Evidence map›Paper›PMID 40933386›Full record

ArticleProceedings of the ... IEEE International Symposium on Applications of Ferroelectrics. IEEE International Symposium on Applications of Ferroelectrics2024

In Vivo Dual-Channel Widefield GCaMP Imaging using Transparent Ultrasound Transducer.

Young Hun Kim, Martin Loynaz Prieto, Chunfu Lin, Yichi Zhang, Kamyar Firouzi, Merritt Maduke, Kim Butts Pauly, Pierre Khuri-Yakub

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Article in Proceedings of the ... IEEE International Symposium on Applications of Ferroelectrics. IEEE International Symposium on Applications of Ferroelectrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Young Hun KimE. L. Ginzton Lab, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
Martin Loynaz PrietoDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.
Chunfu LinE. L. Ginzton Lab, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
Yichi ZhangE. L. Ginzton Lab, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
Kamyar FirouziE. L. Ginzton Lab, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
Merritt MadukeDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.
Kim Butts PaulyDepartment of Radiology, Stanford, University, Stanford, CA, USA.
Pierre Khuri-YakubE. L. Ginzton Lab, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.

Funding

Neurostimulation by Ultrasound: Physical, Biophysical, and Neural MechanismsR01NS112152 · NINDS · STANFORD UNIVERSITY · PI BACCUS, STEPHEN A, BUTTS-PAULY, KIM · 2020 to 2024
$4.9M
NINDS NIH HHS R01 NS112152
6 · The paper itself

Abstract

Widefield GCaMP imaging has become an essential tool in neuroscience, enabling real-time visualization of neuronal activity, particularly in ultrasound neuromodulation studies. However, traditional ultrasound transducers obstruct the light path, thereby complicating the alignment of the optical and acoustic paths. This study introduces a transparent ultrasound transducer (TUT) fabricated from lithium niobate, specifically designed to facilitate the alignment of the optical and acoustic paths. Indium tin oxide (ITO) is used as the transparent electrode of the TUT, providing transmittance higher than 70% at wavelengths critical for GCaMP imaging. This system supports simultaneous ultrasound stimulation and imaging without optical interference, effectively accommodating the needs of dual-channel widefield GCaMP imaging. By alternating between blue and violet light for stimulation, our system allows for the distinction between neural and non-neural activity.

Indexed as

GCaMP ImagingIn VivoNeuromodulationdTransparent Ultrasound Transducer

Identifiers

PMID40933386
PMCPMC12419201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.