ArticleACS catalysis2025
Enantioselective and Diastereoselective Synthesis of Azaspiro[n.2]alkanes by Rhodium-Catalyzed Cyclopropanations.
Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Asymmetric C-H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates.Journal of the American Chemical Society · 2026Article
- Bifunctional Iminophosphorane Superbases Enable the Highly Enantioselective Sulfa-Michael Addition to Fully Substituted Cyclopropene Carboxylic Acid Derivatives.Journal of the American Chemical Society · 2025Article
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Authors and funding
5 authors.
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Abstract
Spirocyclopropanes have become a prevalent structural motif in drug discovery campaigns. However, methods to generate these spirocyclopropanes stereoselectively are scarce, highlighting the need for efficient synthetic methods. In this report, we describe the synthesis of various azaspiro-[n.2]-alkanes by means of a dirhodium tetracarboxylate catalyzed cyclopropanation of exocyclic olefins using donor/acceptor carbenes. The optimum chiral dirhodium tetracarboxylate catalyst, Rh
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